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MedKoo Cat#: 125598 | Name: AMG-900 bismesylate dihydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AMG 900 is a small-molecule inhibitor of Aurora kinases A, B and C with potential antineoplastic activity. Aurora kinase inhibitor AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis and are overexpressed by a wide variety of cancer cell types.

Chemical Structure

AMG-900 bismesylate dihydrate
AMG-900 bismesylate dihydrate
CAS#AMG-900 bismesylate dihydrate

Theoretical Analysis

MedKoo Cat#: 125598

Name: AMG-900 bismesylate dihydrate

CAS#: AMG-900 bismesylate dihydrate

Chemical Formula: C30H33N7O9S3

Exact Mass: 731.1500

Molecular Weight: 731.81

Elemental Analysis: C, 49.24; H, 4.55; N, 13.40; O, 19.68; S, 13.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
AMG-900 bismesylate dihydrate 945595-80-2 (free base)
Synonym
E717YSV70L; AMG-900 bismesylate dihydrate; AMG900 bismesylate dihydrate; AMG 900 bismesylate dihydrate
IUPAC/Chemical Name
N-(4-((3-(2-aminopyrimidin-4-yl)pyridin-2-yl)oxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine dimethanesulfonate dihydrate
InChi Key
LINJGTOZMRMDBO-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H21N7OS.2CH4O3S.2H2O/c1-17-15-24(37-16-17)25-20-5-2-3-6-21(20)26(35-34-25)32-18-8-10-19(11-9-18)36-27-22(7-4-13-30-27)23-12-14-31-28(29)33-23;2*1-5(2,3)4;;/h2-16H,1H3,(H,32,35)(H2,29,31,33);2*1H3,(H,2,3,4);2*1H2
SMILES Code
O.O.CS(O)(=O)=O.CS(O)(=O)=O.CC1=CSC(=C1)C2=NN=C(NC3=CC=C(OC4=NC=CC=C4C5=NC(N)=NC=C5)C=C3)C6=C2C=CC=C6
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 731.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL