10-DEBC, also known as Akt Inhibitor X and CCG-206734, is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt. Inhibition of Akt phosphorylation by this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.
MedKoo Cat#: 574659
Name: 10-DEBC HCl
CAS#: 925681-41-0 (HCl)
Chemical Formula: C20H26Cl2N2O
Exact Mass: 380.1422
Molecular Weight: 381.34
Elemental Analysis: C, 62.99; H, 6.87; Cl, 18.59; N, 7.35; O, 4.20
The following data is based on the product molecular weight 381.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
