CBL0137 (CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).
MedKoo Cat#: 584439
Name: CBL0137 HCl
CAS#: 1197397-89-9 (HCl)
Chemical Formula: C21H25ClN2O2
Exact Mass: 0.0000
Molecular Weight: 372.89
Elemental Analysis: C, 67.64; H, 6.76; Cl, 9.51; N, 7.51; O, 8.58
The following data is based on the product molecular weight 372.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
