MedKoo Cat#: 562704 | Name: CFM-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CFM-1 is an antagonist of anaphase-promoting complex (APC)-2 and cell cycle and apoptosis regulatory protein (CARP)-1 interaction.

Chemical Structure

CFM-1
CFM-1
CAS#1380448-60-1

Theoretical Analysis

MedKoo Cat#: 562704

Name: CFM-1

CAS#: 1380448-60-1

Chemical Formula: C12H7BrN2O2S2

Exact Mass: 353.9132

Molecular Weight: 355.22

Elemental Analysis: C, 40.57; H, 1.99; Br, 22.49; N, 7.89; O, 9.01; S, 18.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
CFM-1; CFM 1; CFM1;
IUPAC/Chemical Name
(3Z)-5-Bromo-1,3-Dihydro-7-methyl-3-(4-oxo-2-thioxo-5-thiazolidinylidene)-2H-Indol-2-one
InChi Key
VLLRKQVBZJEPMJ-CLFYSBASSA-N
InChi Code
InChI=1S/C12H7BrN2O2S2/c1-4-2-5(13)3-6-7(10(16)14-8(4)6)9-11(17)15-12(18)19-9/h2-3H,1H3,(H,14,16)(H,15,17,18)/b9-7-
SMILES Code
O=C1NC2=C(C=C(Br)C=C2C)/C1=C(SC(N3)=S)\C3=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 355.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tavares AC, Bocchi EA, Guimarães GV. Functional Class in Children with Idiopathic Dilated Cardiomyopathy. A pilot Study. Arq Bras Cardiol. 2016 Jun;106(6):502-9. doi: 10.5935/abc.20160066. Epub 2016 May 6. English, Portuguese. PubMed PMID: 27168472; PubMed Central PMCID: PMC4940149. 2: Alafeefy AM, Ashour AE, Prasad O, Sinha L, Pathak S, Alasmari FA, Rishi AK, Abdel-Aziz HA. Development of certain novel N-(2-(2-(2-oxoindolin-3-ylidene)hydrazinecarbonyl)phenyl)-benzamides and 3-(2-oxoindolin-3-ylideneamino)-2-substituted quinazolin-4(3H)-ones as CFM-1 analogs: design, synthesis, QSAR analysis and anticancer activity. Eur J Med Chem. 2015 Mar 6;92:191-201. doi: 10.1016/j.ejmech.2014.12.048. Epub 2014 Dec 27. PubMed PMID: 25555142. 3: Muthu M, Cheriyan VT, Munie S, Levi E, Frank J, Ashour AE, Singh M, Rishi AK. Mechanisms of neuroblastoma cell growth inhibition by CARP-1 functional mimetics. PLoS One. 2014 Jul 17;9(7):e102567. doi: 10.1371/journal.pone.0102567. eCollection 2014. PubMed PMID: 25033461; PubMed Central PMCID: PMC4102511. 4: Khan NA, Raine LB, Drollette ES, Scudder MR, Pontifex MB, Castelli DM, Donovan SM, Evans EM, Hillman CH. Impact of the FITKids physical activity intervention on adiposity in prepubertal children. Pediatrics. 2014 Apr;133(4):e875-83. doi: 10.1542/peds.2013-2246. Epub 2014 Mar 31. PubMed PMID: 24685956; PubMed Central PMCID: PMC3966501. 5: Jamal S, Cheriyan VT, Muthu M, Munie S, Levi E, Ashour AE, Pass HI, Wali A, Singh M, Rishi AK. CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells. PLoS One. 2014 Mar 5;9(3):e89146. doi: 10.1371/journal.pone.0089146. eCollection 2014. PubMed PMID: 24598827; PubMed Central PMCID: PMC3943785. 6: Vermeulen R, Coble JB, Lubin JH, Portengen L, Blair A, Attfield MD, Silverman DT, Stewart PA. The Diesel Exhaust in Miners Study: IV. Estimating historical exposures to diesel exhaust in underground non-metal mining facilities. Ann Occup Hyg. 2010 Oct;54(7):774-88. doi: 10.1093/annhyg/meq025. Epub 2010 Sep 27. PubMed PMID: 20876235; PubMed Central PMCID: PMC2953557. 7: De Sarro G, Di Paola ED, Gareri P, Gallelli L, Scotto G, De Sarro A. Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. Eur J Pharmacol. 1999 Mar 5;368(2-3):149-59. PubMed PMID: 10193651. 8: Wang Z, Deurenberg P, Wang W, Pierson RN Jr, Heymsfield SB. Fraction of carbon-free body mass as oxygen is a constant body composition ratio in men. J Nutr. 1998 Jun;128(6):1008-10. PubMed PMID: 9614161.