Clesacostat, also known PF-05221304, is a potent and selective ACC inhibitor (hACC1 IC50 = 13nM; hACC@ IC50 = 9 nM). PF-0522130 selectively inhibits liver DNL in animals, while demonstrating considerable safety margins against platelet reduction in a nonhuman primate model.
MedKoo Cat#: 124817
Name: Clesacostat tromethamine
CAS#: 2334472-62-5 (tris)
Chemical Formula: C32H41N5O8
Exact Mass: 623.3000
Molecular Weight: 623.71
Elemental Analysis: C, 61.62; H, 6.63; N, 11.23; O, 20.52
The following data is based on the product molecular weight 623.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
