Clesacostat, also known PF-05221304, is a potent and selective ACC inhibitor (hACC1 IC50 = 13nM; hACC@ IC50 = 9 nM). PF-0522130 selectively inhibits liver DNL in animals, while demonstrating considerable safety margins against platelet reduction in a nonhuman primate model.
MedKoo Cat#: 462958
Name: Clesacostat
CAS#: 1370448-25-1 (free)
Chemical Formula: C28H30N4O5
Exact Mass: 502.2216
Molecular Weight: 502.57
Elemental Analysis: C, 66.92; H, 6.02; N, 11.15; O, 15.92
The following data is based on the product molecular weight 502.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
