MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 341468 | Name: Songorine
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Songorine is a biochemical.

Chemical Structure

Songorine
Songorine
CAS#509-24-0

Theoretical Analysis

MedKoo Cat#: 341468

Name: Songorine

CAS#: 509-24-0

Chemical Formula: C22H31NO3

Exact Mass: 357.2304

Molecular Weight: 357.49

Elemental Analysis: C, 73.92; H, 8.74; N, 3.92; O, 13.43

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 650.00 2 Weeks
10mg USD 950.00 2 Weeks
25mg USD 1,450.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Songorine; BRN-0045107; BRN 0045107; BRN0045107.
IUPAC/Chemical Name
Songorine
InChi Key
CBOSLVQFGANWTL-DVPYZRQCSA-N
InChi Code
InChI=1S/C22H31NO3/c1-4-23-10-20(3)6-5-17(25)22-15(20)7-13(18(22)23)21-9-12(11(2)19(21)26)14(24)8-16(21)22/h12-13,15-19,25-26H,2,4-10H2,1,3H3/t12-,13+,15-,16-,17+,18-,19-,20+,21+,22+/m1/s1
SMILES Code
CCN1C[C@@]2(CC[C@@H]([C@@]34[C@@H]2C[C@H]([C@@]56C[C@H](C([C@H]6O)=C)C(C[C@@H]45)=O)[C@@H]13)O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 357.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhao F, Piao J, Song J, Geng Z, Chen H, Cheng Z, Cui R, Li B. Traditional Chinese Herbal Formula, Fuzi-Lizhong Pill, Produces Antidepressant-like Effects in Chronic Restraint Stress Mice through Systemic Pharmacology. J Ethnopharmacol. 2024 Oct 30:119011. doi: 10.1016/j.jep.2024.119011. Epub ahead of print. PMID: 39486672. 2: Ding X, Xu M, Zhang Y, Long C, Su X, Zhang Y, Qiao Y, Zhang X, Zhou Q, Tan G, Ma J. Integration of four-dimensional proteomics and network pharmacology to reveal molecular mechanisms of multi-components multi-targets effects of Sini decoction on myocardial infarction. J Pharm Biomed Anal. 2024 Oct 23;253:116526. doi: 10.1016/j.jpba.2024.116526. Epub ahead of print. PMID: 39486393. 3: Yang X, Xin Y, Gu Y, Wang Y, Hu X, Ying G, Zhang Q, He X. Total alkaloids of Aconitum carmichaelii Debx alleviate cisplatin-induced acute renal injury by inhibiting inflammation and oxidative stress related to gut microbiota metabolism. Phytomedicine. 2024 Oct 9;135:156128. doi: 10.1016/j.phymed.2024.156128. Epub ahead of print. PMID: 39442279. 4: Nesterova YV, Vsyakikh OV, Kul'pin PV, Povetyeva TN, Zyuz'kov GN, Suslov NI, Zhdanov VV, Losev EA. Comparative Study of the Anxiolytic Activity of Songorine in Elevated Plus Maze Test and by Recording Ultrasonic Vocalizations. Bull Exp Biol Med. 2024 Sep;177(5):648-652. doi: 10.1007/s10517-024-06242-5. Epub 2024 Sep 28. PMID: 39340623. 5: Zhang W, Cai S, Luan W, Ding M, Di L. Integrated serum pharmacochemistry, network pharmacology and experimental verification to explore the mechanism of Aconiti Lateralis Radix Praeparata in treatment of lung cancer. J Pharm Biomed Anal. 2025 Jan 1;252:116472. doi: 10.1016/j.jpba.2024.116472. Epub 2024 Sep 11. PMID: 39278160. 6: Zyuz'kov GN, Losev EA, Suslov NI, Miroshnichenko LA, Polyakova TY, Simanina EV, Stavrova LA, Agafonov VI, Danilets MG, Zhdanov VV. Features of Intracellular Signal Transduction in Neural Stem Cells under the Influence of Alkaloid Songorine, an Agonist of Fibroblast Growth Factor Receptors. Bull Exp Biol Med. 2024 Mar;176(5):576-580. doi: 10.1007/s10517-024-06070-7. Epub 2024 May 9. PMID: 38724808. 7: Ge M, Ouyang H, Shang Y, Biu AM, Wu X, Li C, Zuo F, Zhu Y, Xue Z, Hao J, He J. Investigation of the drug-drug interaction and incompatibility mechanism between Aconitum carmichaelii Debx and Pinellia ternata (Thunb.) Breit. J Ethnopharmacol. 2024 Aug 10;330:118212. doi: 10.1016/j.jep.2024.118212. Epub 2024 Apr 16. PMID: 38636577. 8: He XX, Huang YJ, Hu CL, Xu QQ, Wei QJ. Songorine modulates macrophage polarization and metabolic reprogramming to alleviate inflammation in osteoarthritis. Front Immunol. 2024 Feb 13;15:1344949. doi: 10.3389/fimmu.2024.1344949. PMID: 38415250; PMCID: PMC10896988. 9: Li Z, Yuan J, Dai Y, Xia Y. Integration of serum pharmacochemistry and metabolomics to reveal the underlying mechanism of shaoyao-gancao-fuzi decoction to ameliorate rheumatoid arthritis. J Ethnopharmacol. 2024 May 23;326:117910. doi: 10.1016/j.jep.2024.117910. Epub 2024 Feb 17. PMID: 38373664. 10: Chen F, Wang Z, Luo L, He Y, Ma Y, Wen C, Wang X, Shen X. Development of an ultra-high-performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of crassicauline A, fuziline, karacoline, and songorine in rat plasma and application in their pharmacokinetics. Biomed Chromatogr. 2024 Apr;38(4):e5821. doi: 10.1002/bmc.5821. Epub 2024 Jan 13. PMID: 38217347. 11: Chen M, Huang S, Weng S, Weng J, Guo R, Shi B, Liu D. Songorine ameliorates LPS-induced sepsis cardiomyopathy by Wnt/β-catenin signaling pathway-mediated mitochondrial biosynthesis. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jul;397(7):4713-4725. doi: 10.1007/s00210-023-02897-5. Epub 2023 Dec 22. PMID: 38133657. 12: Fang J, Huang Q, Shi C, Gai L, Wang X, Yan B. Songorine inhibits oxidative stress-related inflammation through PI3K/AKT/NRF2 signaling pathway to alleviate lipopolysaccharide-induced septic acute lung injury. Immunopharmacol Immunotoxicol. 2024 Apr;46(2):152-160. doi: 10.1080/08923973.2023.2281902. Epub 2023 Nov 17. PMID: 37977206. 13: Ding X, Zhang Y, Pan P, Long C, Zhang X, Zhuo L, Zhou Q, Liao W, Tan G. Multiple mitochondria-targeted components screened from Sini decoction improved cardiac energetics and mitochondrial dysfunction to attenuate doxorubicin- induced cardiomyopathy. Theranostics. 2023 Jan 1;13(2):510-530. doi: 10.7150/thno.80066. PMID: 36632225; PMCID: PMC9830424. 14: Li X, Hou W, Lin T, Ni J, Qiu H, Fu Y, Zhao Z, Yang C, Li N, Zhou H, Zhang R, Liu Z, Fu L, Zhu L. Neoline, fuziline, songorine and 10-OH mesaconitine are potential quality markers of Fuzi: In vitro and in vivo explorations as well as pharmacokinetics, efficacy and toxicity evaluations. J Ethnopharmacol. 2023 Mar 1;303:115879. doi: 10.1016/j.jep.2022.115879. Epub 2022 Nov 10. PMID: 36370966. 15: Bali ZK, Bruszt N, Kőszegi Z, Nagy LV, Atlasz T, Kovács P, Csupor D, Csupor- Löffler B, Hernádi I. Aconitum Alkaloid Songorine Exerts Potent Gamma- Aminobutyric Acid-A Receptor Agonist Action In Vivo and Effectively Decreases Anxiety without Adverse Sedative or Psychomotor Effects in the Rat. Pharmaceutics. 2022 Sep 28;14(10):2067. doi: 10.3390/pharmaceutics14102067. PMID: 36297502; PMCID: PMC9610616. 16: Wang Q, Peng J, Liu Y, Tian Y, Li J, Ren YY, Gu J, Tan R. [Therapeutic effects of alkaloids in Tibetan medicine Bangna (Aconiti Penduli et Aconiti Flavi Radix) on osteoarthritis rats and mechanisms]. Zhongguo Zhong Yao Za Zhi. 2022 Sep;47(17):4715-4722. Chinese. doi: 10.19540/j.cnki.cjcmm.20220207.704. PMID: 36164879. 17: Yuan H, Liu Y, Huang K, Hao H, Xue YT. Therapeutic Mechanism and Key Active Ingredients of Shenfu Injection in Sepsis: A Network Pharmacology and Molecular Docking Approach. Evid Based Complement Alternat Med. 2022 Aug 26;2022:9686149. doi: 10.1155/2022/9686149. PMID: 36062176; PMCID: PMC9439916. 18: Jin S, Zhao X, Ma D. Divergent Total Syntheses of Napelline-Type C20-Diterpenoid Alkaloids: (-)-Napelline, (+)-Dehydronapelline, (-)-Songorine, (-)-Songoramine, (-)-Acoapetaldine D, and (-)-Liangshanone. J Am Chem Soc. 2022 Aug 24;144(33):15355-15362. doi: 10.1021/jacs.2c06738. Epub 2022 Aug 10. PMID: 35948501. 19: Chen ZY, Wei XY, Qiu ZD, Huang Y, Tan T, Feng YL, Guo J, Cui GH, Huang LQ, Lai CJ. Compatibility of Fuzi and Ginseng Significantly Increase the Exposure of Aconitines. Front Pharmacol. 2022 Apr 26;13:883898. doi: 10.3389/fphar.2022.883898. PMID: 35662724; PMCID: PMC9156935. 20: Zhang L, Siyiti M, Zhang J, Yao M, Zhao F. Anti-inflammatory and anti- rheumatic activities in vitro of alkaloids separated from Aconitum soongoricum Stapf. Exp Ther Med. 2021 May;21(5):493. doi: 10.3892/etm.2021.9924. Epub 2021 Mar 17. PMID: 33791002; PMCID: PMC8005664.