MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 341549 | Name: Iproxamine hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Iproxamine hydrochloride is a biochemical.

Chemical Structure

Iproxamine hydrochloride
Iproxamine hydrochloride
CAS#51222-37-8

Theoretical Analysis

MedKoo Cat#: 341549

Name: Iproxamine hydrochloride

CAS#: 51222-37-8

Chemical Formula: C18H30ClNO4

Exact Mass: 359.1863

Molecular Weight: 359.89

Elemental Analysis: C, 60.07; H, 8.40; Cl, 9.85; N, 3.89; O, 17.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Iproxamine hydrochloride ; W 42782; W-42782; W42782.
IUPAC/Chemical Name
Carbonic acid, 4-(2-(dimethylamino)ethoxy)-2-methyl-5-(1-methylethyl)phenyl 1-methylethyl ester, hydrochloride
InChi Key
PJQYWYGKLCIALW-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H29NO4.ClH/c1-12(2)15-11-16(23-18(20)22-13(3)4)14(5)10-17(15)21-9-8-19(6)7;/h10-13H,8-9H2,1-7H3;1H
SMILES Code
O=C(OC(C)C)OC1=CC(C(C)C)=C(OCCN(C)C)C=C1C.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 359.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rahme K, Guo J, Holmes JD, O'Driscoll CM. Evaluation of the physicochemical properties and the biocompatibility of polyethylene glycol-conjugated gold nanoparticles: A formulation strategy for siRNA delivery. Colloids Surf B Biointerfaces. 2015 Nov 1;135:604-12. doi: 10.1016/j.colsurfb.2015.08.032. Epub 2015 Aug 24. PubMed PMID: 26322474. 2: Yassin AA, Elwaseef AM, Elnashar MM, Oldenburg J, Mayer G, Pötzsch B, Müller J. Protamine-adsorbed magnetic nanoparticles for efficient isolation and concentration of hepatitis-C virus from human plasma samples. Chem Commun (Camb). 2014 Jan 18;50(5):590-2. doi: 10.1039/c3cc46793g. Epub 2013 Nov 25. PubMed PMID: 24275772. 3: Mori N, Ohno J, Sakagami R, Hayakawa T, Fukushima T. Cell viabilities and biodegradation rates of DNA/protamine complexes with two different molecular weights of DNA. J Biomed Mater Res B Appl Biomater. 2013 Jul;101(5):743-51. doi: 10.1002/jbm.b.32877. Epub 2013 Jan 29. PubMed PMID: 23359567. 4: Meyer-Ficca ML, Lonchar JD, Ihara M, Meistrich ML, Austin CA, Meyer RG. Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis. Biol Reprod. 2011 May;84(5):900-9. doi: 10.1095/biolreprod.110.090035. Epub 2011 Jan 12. PubMed PMID: 21228215; PubMed Central PMCID: PMC3080419. 5: Reibetanz U, Chen MH, Mutukumaraswamy S, Liaw ZY, Oh BH, Donath E, Neu B. Functionalization of calcium carbonate microparticles as a combined sensor and transport system for active agents in cells. J Biomater Sci Polym Ed. 2011;22(14):1845-59. doi: 10.1163/092050610X528552. Epub 2010 Oct 19. PubMed PMID: 20961492. 6: Reibetanz U, Chen MH, Mutukumaraswamy S, Liaw ZY, Oh BH, Venkatraman S, Donath E, Neu B. Colloidal DNA carriers for direct localization in cell compartments by pH sensoring. Biomacromolecules. 2010 Jul 12;11(7):1779-84. doi: 10.1021/bm100237r. PubMed PMID: 20550107. 7: He C, Hu Y, Yin L, Tang C, Yin C. Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials. 2010 May;31(13):3657-66. doi: 10.1016/j.biomaterials.2010.01.065. Epub 2010 Feb 6. PubMed PMID: 20138662. 8: Ohsu T, Amino Y, Nagasaki H, Yamanaka T, Takeshita S, Hatanaka T, Maruyama Y, Miyamura N, Eto Y. Involvement of the calcium-sensing receptor in human taste perception. J Biol Chem. 2010 Jan 8;285(2):1016-22. doi: 10.1074/jbc.M109.029165. Epub 2009 Nov 5. PubMed PMID: 19892707; PubMed Central PMCID: PMC2801228. 9: Shutava TG, Balkundi SS, Vangala P, Steffan JJ, Bigelow RL, Cardelli JA, O'Neal DP, Lvov YM. Layer-by-Layer-Coated Gelatin Nanoparticles as a Vehicle for Delivery of Natural Polyphenols. ACS Nano. 2009 Jul 28;3(7):1877-85. doi: 10.1021/nn900451a. Epub 2009 Jun 17. PubMed PMID: 19534472. 10: Zaki NM, Mortada ND, Awad GA, Abd ElHady SS. Rapid-onset intranasal delivery of metoclopramide hydrochloride Part II: Safety of various absorption enhancers and pharmacokinetic evaluation. Int J Pharm. 2006 Dec 11;327(1-2):97-103. Epub 2006 Jul 25. PubMed PMID: 16959453. 11: Zaki NM, Awad GA, Mortada ND, Abd ElHady SS. Rapid-onset intranasal delivery of metoclopramide hydrochloride. Part I. Influence of formulation variables on drug absorption in anesthetized rats. Int J Pharm. 2006 Dec 11;327(1-2):89-96. Epub 2006 Jul 25. PubMed PMID: 16942844. 12: Mittermayr M, Margreiter J, Velik-Salchner C, Klingler A, Streif W, Fries D, Innerhofer P. Effects of protamine and heparin can be detected and easily differentiated by modified thrombelastography (Rotem): an in vitro study. Br J Anaesth. 2005 Sep;95(3):310-6. Epub 2005 Jul 15. PubMed PMID: 16024582. 13: He SH, Chen P, Chen HQ. Modulation of enzymatic activity of human mast cell tryptase and chymase by protease inhibitors. Acta Pharmacol Sin. 2003 Sep;24(9):923-9. PubMed PMID: 12956943. 14: Suyama K, Muso E, Yashiro M, Sasayama S. Significant suppressive effect of low-dose temocapril, an ACE inhibitor with biliary excretion, on FGS lesions in hypertensive rats. Nephron. 2000 Dec;86(4):491-8. PubMed PMID: 11124599. 15: Berlis A, Schumacher M. [Anticoagulation control during neuroradiological interventions with ACT (activated clotting time)]. Rofo. 1999 Apr;170(4):378-83. German. PubMed PMID: 10341797. 16: Markland P, Amidon GL, Yang VC. Modified polypeptides containing gamma-benzyl glutamic acid as drug delivery platforms. Int J Pharm. 1999 Feb 15;178(2):183-92. PubMed PMID: 10205638. 17: Kanbak M, Kahraman S, Celebioglu B, Akpolat N, Ercan S, Erdem K. Prophylactic administration of histamine 1 and/or histamine 2 receptor blockers in the prevention of heparin- and protamine-related haemodynamic effects. Anaesth Intensive Care. 1996 Oct;24(5):559-63. PubMed PMID: 8909666. 18: Stiekema JC, Wijnand HP, ten Cate H, ten Cate JW, Harenberg J, Egberts JF, van Dinther TG. Partial in vivo neutralisation of plasma anticoagulant effects of Lomoparan (Org 10172) by protamine chloride. Thromb Res. 1991 Jul 1;63(1):157-67. PubMed PMID: 1948817. 19: Bellvé AR, McKay DJ, Renaux BS, Dixon GH. Purification and characterization of mouse protamines P1 and P2. Amino acid sequence of P2. Biochemistry. 1988 Apr 19;27(8):2890-7. PubMed PMID: 3401454. 20: Velders AJ, Wildevuur CR. Platelet damage by protamine and the protective effect of prostacyclin: an experimental study in dogs. Ann Thorac Surg. 1986 Aug;42(2):168-71. PubMed PMID: 3527093.