MedKoo Cat#: 127267 | Name: Propizepine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Propizepine is a benzodiazepinone derivative. It is an antidepressive, antihistaminic, antianaphylactic, thymoanaleptic, antiserotonine, antispasmodic, and analgetic compound.

Chemical Structure

Propizepine
Propizepine
CAS#10321-12-7 (free base)

Theoretical Analysis

MedKoo Cat#: 127267

Name: Propizepine

CAS#: 10321-12-7 (free base)

Chemical Formula: C17H20N4O

Exact Mass: 296.1637

Molecular Weight: 296.37

Elemental Analysis: C, 68.90; H, 6.80; N, 18.90; O, 5.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
PROPIZEPINE; PROPIEZEPINE, (±)-; (±)-PROPIEZEPINE; UP 106; VAGRAN 50
IUPAC/Chemical Name
6-(2-(dimethylamino)propyl)-6,11-dihydro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-5-one
InChi Key
YFLBETLXDPBWTD-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H20N4O/c1-12(20(2)3)11-21-15-9-5-4-8-14(15)19-16-13(17(21)22)7-6-10-18-16/h4-10,12H,11H2,1-3H3,(H,18,19)
SMILES Code
CC(CN1C2=C(NC3=C(C=CC=N3)C1=O)C=CC=C2)N(C)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 296.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kopanski C, Türck M, Schultz JE. Effects of long-term treatment of rats with antidepressants on adrenergic-receptor sensitivity in cerebral cortex: Structure activity study. Neurochem Int. 1983;5(5):649-59. doi: 10.1016/0197-0186(83)90059-1. PMID: 20487994. 2: Kamal A, Reddy KL, Devaiah V, Shankaraiah N, Reddy DR. Recent advances in the solid-phase combinatorial synthetic strategies for the benzodiazepine based privileged structures. Mini Rev Med Chem. 2006 Jan;6(1):53-69. doi: 10.2174/138955706775197875. PMID: 16457632. 3: Rajagopalan R, Bandyopadhyaya A, Rajagopalan DR, Rajagopalan P. The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds. Bioorg Med Chem Lett. 2014 Jan 15;24(2):576-9. doi: 10.1016/j.bmcl.2013.12.024. Epub 2013 Dec 11. PMID: 24365159. 4: Ellenbroek BA, Liégeois JF, Bruhwyler J, Cools AR. Effects of JL13, a pyridobenzoxazepine with potential atypical antipsychotic activity, in animal models for schizophrenia. J Pharmacol Exp Ther. 2001 Jul;298(1):386-91. PMID: 11408566. 5: Dereux JF. Le Vagran 50: un antidépresseur situationnel [Vagran 50: a situational antidepressant]. Sem Hop Ther. 1976 Sep-Oct;52(7-8):385-8. French. PMID: 996559. 6: Shi F, Xu X, Zheng L, Dang Q, Bai X. Method development for a pyridobenzodiazepine library with multiple diversification points. J Comb Chem. 2008 Mar-Apr;10(2):158-61. doi: 10.1021/cc7002039. Epub 2008 Feb 9. PMID: 18260649. 7: Lwoff JM, Larousse C, Simon P, Boissier JR. Profil psychopharmacologique d'un antidépresseur potentiel appartenant à la série pyridobenzodiazépine [Psychopharmacological pattern of a potential antidepressive drug of the pyridobenzodiazepine series]. Therapie. 1971 May-Jun;26(3):451-7. French. PMID: 5113799.