MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 562616 | Name: IHR-1
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IHR-1 is a synthetic inhibitor targeting the hypoxia-inducible factor-1 (HIF-1) signaling pathway, which plays a central role in cellular adaptation to low oxygen conditions. It exerts its bioactivity by interfering with HIF-1α stabilization and/or its transcriptional activity, thereby reducing the expression of downstream genes involved in angiogenesis, metabolism, and cell survival. By attenuating HIF-1-mediated gene expression, IHR-1 has potential applications in studying cancer biology, particularly tumor hypoxia and its role in therapeutic resistance.

Chemical Structure

IHR-1
IHR-1
CAS#548779-60-8

Theoretical Analysis

MedKoo Cat#: 562616

Name: IHR-1

CAS#: 548779-60-8

Chemical Formula: C20H12Cl4N2O2

Exact Mass: 451.9653

Molecular Weight: 454.13

Elemental Analysis: C, 52.90; H, 2.66; Cl, 31.22; N, 6.17; O, 7.05

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 1,950.00 2 Weeks
1g USD 2,850.00 2 Weeks
2g USD 4,850.00 2 Weeks
Show More
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
548779-60-8
Synonym
IHR-1; IHR 1; IHR1;
IUPAC/Chemical Name
N,N'-(1,4-phenylene)bis(2,5-dichlorobenzamide)
InChi Key
VCLHHRGZKNUOAQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H12Cl4N2O2/c21-11-1-7-17(23)15(9-11)19(27)25-13-3-5-14(6-4-13)26-20(28)16-10-12(22)2-8-18(16)24/h1-10H,(H,25,27)(H,26,28)
SMILES Code
ClC1=C(C(NC2=CC=C(NC(C3=CC(Cl)=CC=C3Cl)=O)C=C2)=O)C=C(Cl)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
IHR-1 is a cell membrane impermeable Smo antagonist.
In vitro activity:
Using a cell-membrane-impermeable Smo antagonist (IHR-1), this study demonstrates that Smo supplied with a synthetic agonist or activated with oncogenic mutations can signal without ciliary accumulation. Similarly, cells with compromised ciliary Smo trafficking due to loss of the phosphatidylinositol-4-phosphate 3-kinase (PI3K)-C2α retain transcriptional response to an exogenously supplied Smo agonist. Reference: Chem Biol. 2014 Dec 18;21(12):1680-9. https://pubmed.ncbi.nlm.nih.gov/25484239/
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 9.1 19.99
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 454.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Fan CW, Chen B, Franco I, Lu J, Shi H, Wei S, Wang C, Wu X, Tang W, Roth MG, Williams NS, Hirsch E, Chen C, Lum L. The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem Biol. 2014 Dec 18;21(12):1680-9. doi: 10.1016/j.chembiol.2014.10.013. Epub 2014 Dec 4. Erratum in: Chem Biol. 2015 Apr 23;22(4):559. PMID: 25484239; PMCID: PMC4272670. 2. Sun H, Skogerbø G, Zheng X, Liu W, Li Y. Genomic regions with distinct genomic distance conservation in vertebrate genomes. BMC Genomics. 2009 Mar 27;10:133. doi: 10.1186/1471-2164-10-133. PMID: 19323843; PMCID: PMC2667192.
In vitro protocol:
1. Fan CW, Chen B, Franco I, Lu J, Shi H, Wei S, Wang C, Wu X, Tang W, Roth MG, Williams NS, Hirsch E, Chen C, Lum L. The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem Biol. 2014 Dec 18;21(12):1680-9. doi: 10.1016/j.chembiol.2014.10.013. Epub 2014 Dec 4. Erratum in: Chem Biol. 2015 Apr 23;22(4):559. PMID: 25484239; PMCID: PMC4272670. 2. Sun H, Skogerbø G, Zheng X, Liu W, Li Y. Genomic regions with distinct genomic distance conservation in vertebrate genomes. BMC Genomics. 2009 Mar 27;10:133. doi: 10.1186/1471-2164-10-133. PMID: 19323843; PMCID: PMC2667192.
In vivo protocol:
TBD
Fan CW, Chen B, Franco I, Lu J, Shi H, Wei S, Wang C, Wu X, Tang W, Roth MG, Williams NS, Hirsch E, Chen C, Lum L. The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem Biol. 2014 Dec 18;21(12):1680-9. doi: 10.1016/j.chembiol.2014.10.013. Epub 2014 Dec 4. Erratum in: Chem Biol. 2015 Apr 23;22(4):559. PMID: 25484239; PMCID: PMC4272670.

View History

JNJ-17156516

JNJ-17156516

BT-Sch

BT-Sch

Samandarine

Samandarine

FPL-64170XX

FPL-64170XX