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MedKoo Cat#: 562558 | Name: DNAC-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DNAC-1 is a potentiator of β-lactam activity against Gram positive and Gram negative pathogens.

Chemical Structure

DNAC-1
DNAC-1
CAS#1006021-30-2

Theoretical Analysis

MedKoo Cat#: 562558

Name: DNAC-1

CAS#: 1006021-30-2

Chemical Formula: C11H9BrN2S2

Exact Mass: 311.9391

Molecular Weight: 313.23

Elemental Analysis: C, 42.18; H, 2.90; Br, 25.51; N, 8.94; S, 20.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DNAC-1; DNAC 1; DNAC1;
IUPAC/Chemical Name
3-(5-Bromo-3,4-dimethyl-thieno[2,3-b]thiophen-2-yl)-1H-pyrazole
InChi Key
MUNXAASMRMRSCE-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H9BrN2S2/c1-5-8-6(2)10(12)16-11(8)15-9(5)7-3-4-13-14-7/h3-4H,1-2H3,(H,13,14)
SMILES Code
CC1=C(Br)SC2=C1C(C)=C(C3=NNC=C3)S2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 313.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nair DR, Monteiro JM, Memmi G, Thanassi J, Pucci M, Schwartzman J, Pinho MG, Cheung AL. Characterization of a novel small molecule that potentiates β-lactam activity against gram-positive and gram-negative pathogens. Antimicrob Agents Chemother. 2015 Apr;59(4):1876-85. doi: 10.1128/AAC.04164-14. Epub 2015 Jan 12. PubMed PMID: 25583731; PubMed Central PMCID: PMC4356822. 2: Galletto R, Bujalowski W. The E. coli replication factor DnaC protein exists in two conformations with different nucleotide binding capabilities. I. Determination of the binding mechanism using ATP and ADP fluorescent analogues. Biochemistry. 2002 Jul 16;41(28):8907-20. PubMed PMID: 12102633.