BLK degrader 1 | compound 9 | CAS#3049215-64-4 | selective degrader of B-lymphoid tyrosine kinase (BLK)

MedKoo Cat#: 124597 | Name: BLK degrader 1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BLK degrader 1 (compound 9) is a selective degrader of B-lymphoid tyrosine kinase (BLK).

Chemical Structure

BLK degrader 1

CAS#3049215-64-4

Theoretical Analysis

MedKoo Cat#: 124597

Name: BLK degrader 1

CAS#: 3049215-64-4

Chemical Formula: C32H25F3N6O2

Exact Mass: 582.1991

Molecular Weight: 582.59

Elemental Analysis: C, 65.97; H, 4.33; F, 9.78; N, 14.43; O, 5.49

Price and Availability

Size	Price	Availability
100mg	USD 1,250.00	2 Weeks
200mg	USD 2,050.00	2 Weeks
500mg	USD 3,250.00	2 Weeks
1g	USD 4,650.00	2 Weeks
2g	USD 6,950.00	2 Weeks

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Related CAS #

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Synonym

BLK-degrader1; BLK degrader-1; BLK degrader 1; Compound 9

IUPAC/Chemical Name

N-(3-((2-((3-aminophenyl)amino)pyrimidin-5-yl)carbamoyl)-4-methylphenyl)-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxamide

InChi Key

MGJRUWHJBSOWPN-UHFFFAOYSA-N

InChi Code

InChI=1S/C32H25F3N6O2/c1-19-8-13-26(39-29(42)21-11-9-20(10-12-21)22-4-2-5-23(14-22)32(33,34)35)16-28(19)30(43)40-27-17-37-31(38-18-27)41-25-7-3-6-24(36)15-25/h2-18H,36H2,1H3,(H,39,42)(H,40,43)(H,37,38,41)

SMILES Code

CC1=CC=C(C=C1C(NC2=CN=C(N=C2)NC3=CC=CC(N)=C3)=O)NC(C4=CC=C(C=C4)C5=CC(C(F)(F)F)=CC=C5)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 582.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Fu T, Zuo Y, Xue G, Zhou D, Pan Z. Discovery of 2,5-diaminopyrimidine derivatives as the first series of selective monomeric degraders of B-lymphoid tyrosine kinase. Eur J Med Chem. 2023 Aug 5;256:115460. doi: 10.1016/j.ejmech.2023.115460. Epub 2023 May 5. PMID: 37163946.