Dacuronium bromide | CAS# 27115-86-2 | neuromuscular blocking agent

MedKoo Cat#: 581187 | Name: Dacuronium bromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dacuronium bromide is an aminosteroid neuromuscular blocking agent Pancuronium (P178500) with much weaker activity which was never marketed. It acts as a competitive antagonist of the nicotinic acetylcholine receptor (nAChR).

Chemical Structure

Dacuronium bromide

CAS#27115-86-2 (bromide)

Theoretical Analysis

MedKoo Cat#: 581187

Name: Dacuronium bromide

CAS#: 27115-86-2 (bromide)

Chemical Formula: C33H58Br2N2O3

Exact Mass: 0.0000

Molecular Weight: 690.65

Elemental Analysis: C, 57.39; H, 8.47; Br, 23.14; N, 4.06; O, 6.95

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Related CAS #

43021-45-0 (cation) 27115-86-2 (bromide)

Synonym

Dacuronium bromide; Dacuronii bromidum; EINECS 248-233-9; NB 68; NB68; NB-68; ORG 6368; ORG6368; ORG-6368;

IUPAC/Chemical Name

[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-hydroxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;dibromide

InChi Key

SUKULMJPMHYWKC-GMMLHHOXSA-L

InChi Code

InChI=1S/C33H58N2O3.2BrH/c1-23(36)38-30-20-24-12-13-25-26(33(24,3)22-29(30)35(5)18-10-7-11-19-35)14-15-32(2)27(25)21-28(31(32)37)34(4)16-8-6-9-17-34;;/h24-31,37H,6-22H2,1-5H3;2*1H/q+2;;/p-2/t24-,25+,26-,27-,28-,29-,30-,31-,32-,33-;;/m0../s1

SMILES Code

CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1[N+]4(CCCCC4)C)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5O)[N+]6(CCCCC6)C)C.[Br-].[Br-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Dacuronium bromide acts as a competitive antagonist of the nicotinic acetylcholine receptor (nAChR).

In vitro activity:

In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 690.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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