Synonym
L 640876; L-640876; L640876; L-640,876; L 640,876; L640,876;
IUPAC/Chemical Name
(6R,7R)-7-((1-benzylpyridin-1-ium-4-yl)amino)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key
MZRVUZHPHNYXTK-YLJYHZDGSA-N
InChi Code
InChI=1S/C22H21N7O3S2/c1-27-22(24-25-26-27)34-13-15-12-33-20-17(19(30)29(20)18(15)21(31)32)23-16-7-9-28(10-8-16)11-14-5-3-2-4-6-14/h2-10,17,20H,11-13H2,1H3,(H,31,32)/t17-,20-/m1/s1
SMILES Code
O=C1[C@@H](NC2=CC=[N+](CC3=CC=CC=C3)C=C2)[C@@]4([H])SCC(CSC5=NN=NN5C)=C(C([O-])=O)N14
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
495.57
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Jacks TM, Schleim KD, Miller BM, Shungu DL, Weinberg E, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. V. L-640,876 treatment of induced enterotoxigenic colibacillosis (scours) in calves and piglets. J Antibiot (Tokyo). 1983 Jan;36(1):70-5. PubMed PMID: 6381448.
2: Koupal LR, Pelak BA, Cassidy PJ, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. III. The mode of action of L-640,876 and the effect of NaCl on membrane permeability and binding. J Antibiot (Tokyo). 1983 Jan;36(1):54-63. PubMed PMID: 6381447.
3: Celozzi E, Pelak BA, Stapley EO, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. IV. Comparison of the in vivo antibacterial activities of L-640,876, mecillinam, cefoxitin and cefotaxime. J Antibiot (Tokyo). 1983 Jan;36(1):64-9. PubMed PMID: 6088459.
4: Koupal LR, Weissberger B, Shungu DL, Weinberg E, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. II. The in vitro antibacterial properties of L-640,876, a new type of beta-lactam antibiotic. J Antibiot (Tokyo). 1983 Jan;36(1):47-53. PubMed PMID: 6088458.
