L 640876 | CAS#77527-71-0 | semisynthetic antibiotic

MedKoo Cat#: 596576 | Name: L 640876

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 640876 is a semisynthetic antibiotic.

Chemical Structure

L 640876

CAS#77527-71-0

Theoretical Analysis

MedKoo Cat#: 596576

Name: L 640876

CAS#: 77527-71-0

Chemical Formula: C22H21N7O3S2

Exact Mass: 495.1147

Molecular Weight: 495.57

Elemental Analysis: C, 53.32; H, 4.27; N, 19.78; O, 9.69; S, 12.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

L 640876; L-640876; L640876; L-640,876; L 640,876; L640,876;

IUPAC/Chemical Name

(6R,7R)-7-((1-benzylpyridin-1-ium-4-yl)amino)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

InChi Key

MZRVUZHPHNYXTK-YLJYHZDGSA-N

InChi Code

InChI=1S/C22H21N7O3S2/c1-27-22(24-25-26-27)34-13-15-12-33-20-17(19(30)29(20)18(15)21(31)32)23-16-7-9-28(10-8-16)11-14-5-3-2-4-6-14/h2-10,17,20H,11-13H2,1H3,(H,31,32)/t17-,20-/m1/s1

SMILES Code

O=C1[C@@H](NC2=CC=[N+](CC3=CC=CC=C3)C=C2)[C@@]4([H])SCC(CSC5=NN=NN5C)=C(C([O-])=O)N14

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 495.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jacks TM, Schleim KD, Miller BM, Shungu DL, Weinberg E, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. V. L-640,876 treatment of induced enterotoxigenic colibacillosis (scours) in calves and piglets. J Antibiot (Tokyo). 1983 Jan;36(1):70-5. PubMed PMID: 6381448. 2: Koupal LR, Pelak BA, Cassidy PJ, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. III. The mode of action of L-640,876 and the effect of NaCl on membrane permeability and binding. J Antibiot (Tokyo). 1983 Jan;36(1):54-63. PubMed PMID: 6381447. 3: Celozzi E, Pelak BA, Stapley EO, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. IV. Comparison of the in vivo antibacterial activities of L-640,876, mecillinam, cefoxitin and cefotaxime. J Antibiot (Tokyo). 1983 Jan;36(1):64-9. PubMed PMID: 6088459. 4: Koupal LR, Weissberger B, Shungu DL, Weinberg E, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. II. The in vitro antibacterial properties of L-640,876, a new type of beta-lactam antibiotic. J Antibiot (Tokyo). 1983 Jan;36(1):47-53. PubMed PMID: 6088458.