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MedKoo Cat#: 581189 | Name: Dacuronium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dacuronium is a new steroidal drug of the neuromuscular blocking properties.Dacuronium produced a competitive type of neuromuscular block with a potency of approximately one-tenth that of tubocurarine and one-fiftieth that of pancuronium. Dacuronium, on the other hand, would appear to have marked chronotropic effects at dose levels needed for adequate neuromuscular blockade.

Chemical Structure

Dacuronium
Dacuronium
CAS#43021-45-0 (cation)

Theoretical Analysis

MedKoo Cat#: 581189

Name: Dacuronium

CAS#: 43021-45-0 (cation)

Chemical Formula: C33H58N2O32+

Exact Mass: 530.4436

Molecular Weight: 530.84

Elemental Analysis: Chemical Formula: C33H58N2O32+ Exact Mass: 530.4436 Molecular Weight: 530.8369 Elemental Analysis: C, 74.67; H, 11.01; N, 5.28; O, 9.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
43021-45-0 (cation) 27115-86-2 (bromide)
Synonym
Dacuronium; 17-Hydroxypancuronium; Androstane, piperidinium deriv; UNII-VD6L56ZVX1;
IUPAC/Chemical Name
1,1'-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-acetoxy-17-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-2,16-diyl)bis(1-methylpiperidin-1-ium)
InChi Key
XQFBAGUGBNQLRT-ZZZJANDJSA-N
InChi Code
InChI=1S/C33H58N2O3/c1-23(36)38-30-20-24-12-13-25-26(33(24,3)22-29(30)35(5)18-10-7-11-19-35)14-15-32(2)27(25)21-28(31(32)37)34(4)16-8-6-9-17-34/h24-31,37H,6-22H2,1-5H3/q+2/t24-,25+,26-,27-,28-,29-,30-,31-,32-,33-/m0/s1
SMILES Code
CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@H](CC[C@]4(C)[C@@H](O)[C@H](C[C@@H]34)[N+]5(C)CCCCC5)[C@@]2(C)C[C@@H]1[N+]6(C)CCCCC6
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 530.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Baden JM. Anticholinergic actions of steroid muscle relaxants. Anaesthesia. 1976 Mar;31(2):215-8. PubMed PMID: 937668. 2: Koo YA, Lee B, Park HJ, Choi J, Lee E, Choi D. Altered vascular endothelial growth factor expression during GnRH antagonist protocol in women of reproductive age with normal baseline hormone profiles. Fertil Steril. 2009 Mar;91(3):744-8. doi: 10.1016/j.fertnstert.2007.12.068. Epub 2008 Mar 5. PubMed PMID: 18321491. 3: Rechberger T, Baranowski W, Bogusiewicz M, Postawski K, Jakimiuk AJ, Tomaszewski J, Kulik-Rechberger B, Jakowicki JA. Serum concentrations of markers of type I collagen metabolism in women taking monophasic oral contraceptives. Ginekol Pol. 2002 Feb;73(2):81-6. PubMed PMID: 12001776. 4: Streuli I, Fraisse T, Pillet C, Ibecheole V, Bischof P, de Ziegler D. Serum antimüllerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids. Fertil Steril. 2008 Aug;90(2):395-400. Epub 2007 Oct 24. PubMed PMID: 17919608. 5: Feldman SA, Tyrrell MF. A new steroid muscle relaxant. Dacuronium-NB.68 (Organon). Anaesthesia. 1970 Jul;25(3):349-55. PubMed PMID: 4246972. 6: Mercilon--a new low-dose combined oral contraceptive. Drug Ther Bull. 1989 Jun 26;27(13):51-2. Erratum in: Drug Ther Bull 1989 Oct 2;27(20):80. PubMed PMID: 2535273. 7: Fotherby K. Clinical experience and pharmacological effects of an oral contraceptive containing 20 micrograms oestrogen. Contraception. 1992 Nov;46(5):477-88. Review. PubMed PMID: 1458894. 8: Uchikova E, Malinova M, Pekhlivanov B, Ledzhev I. [Hemostatic profile of women using low-dose oral contraceptive Mercilon. (Preliminary report)]. Akush Ginekol (Sofiia). 2002;41(3):23-5. Bulgarian. PubMed PMID: 12145973. 9: Kirkman RJ, Pedersen JH, Fioretti P, Roberts HE. Clinical comparison of two low-dose oral contraceptives, Minulet and Mercilon, in women over 30 years of age. Contraception. 1994 Jan;49(1):33-46. PubMed PMID: 8137624. 10: Agoston S, Crul EJ, Kersten UW, Houwertjes MC, Scaf AH. The relationship between disposition and duration of action of congeneric series of steroidal neuromuscular blocking agents. Acta Anaesthesiol Scand. 1977;21(1):24-30. PubMed PMID: 842267. 11: Norman J, Katz RL. Some effects of the steroidal muscle relaxant, dacuronium bromide, in anaesthetized patients. Br J Anaesth. 1971 Apr;43(4):313-9. PubMed PMID: 4252525. 12: Basdevant A, Conard J, Pelissier C, Guyene TT, Lapousterle C, Mayer M, Guy-Grand B, Degrelle H. Hemostatic and metabolic effects of lowering the ethinyl-estradiol dose from 30 mcg to 20 mcg in oral contraceptives containing desogestrel. Contraception. 1993 Sep;48(3):193-204. PubMed PMID: 8222650. 13: Akerlund M, Røde A, Westergaard J. Comparative profiles of reliability, cycle control and side effects of two oral contraceptive formulations containing 150 micrograms desogestrel and either 30 micrograms or 20 micrograms ethinyl oestradiol. Br J Obstet Gynaecol. 1993 Sep;100(9):832-8. PubMed PMID: 8218004. 14: Coenen CM, Thomas CM, Borm GF, Hollanders JM, Rolland R. Changes in androgens during treatment with four low-dose contraceptives. Contraception. 1996 Mar;53(3):171-6. PubMed PMID: 8689882. 15: Song S, Chen JK, Yang PJ, He ML, Li LM, Fan BC, Rekers H, Fotherby K. A cross-over study of three oral contraceptives containing ethinyloestradiol and either desogestrel or levonorgestrel. Contraception. 1992 Jun;45(6):523-32. PubMed PMID: 1535580. 16: Booij LH, Vree TB, Crul JE. Org-NC45: a new steroidal non-depolarizing muscle relaxant. Pharm Weekbl Sci. 1982 Feb 19;4(1):1-4. Review. PubMed PMID: 6122196. 17: Djurica S, Cirović M, Lukić B, Gregorić G, Tasovac-Ponomarev D. Some extrathyroid regulatory mechanisms' aspects in thyroid humoral state at the delivery. Mater Med Pol. 1990 Jul-Sep;22(3):198-201. PubMed PMID: 2132426. 18: Lukić B, Barjaktarović N. Sister-chromatid exchanges in newborns after normal and progesterone-treated pregnancies. Mutat Res. 1987 Jun;191(2):121-4. PubMed PMID: 3600694. 19: Minnema MC, Janssen HL, Niermeijer P, de Man RA. Budd-Chiari syndrome: combination of genetic defects and the use of oral contraceptives leading to hypercoagulability. J Hepatol. 2000 Sep;33(3):509-12. PubMed PMID: 11020010.

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