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MedKoo Cat#: 581140 | Name: Splenopentin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Splenopentin, also known as SP-5, is a synthetic immunomodulating peptide corresponding to the region 32-34 of a splenic product called splenin (SP) and the thymic hormone thymopoietin (TP), respectively. Splenopentin can reproduce the biological activities of TP and SP, respectively.

Chemical Structure

Splenopentin
Splenopentin
CAS#75957-60-7 (free base)

Theoretical Analysis

MedKoo Cat#: 581140

Name: Splenopentin

CAS#: 75957-60-7 (free base)

Chemical Formula: C31H51N9O9

Exact Mass: 693.3810

Molecular Weight: 693.80

Elemental Analysis: C, 53.67; H, 7.41; N, 18.17; O, 20.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
75957-60-7 (free base) 105184-37-0 (Acetate)
Synonym
Splenopentin; Arg-lys-glu-val-tyr; Splenin pentapeptide (32-36); Thymopoietin III pentapeptide (32-36);
IUPAC/Chemical Name
(6S,9S,12S,15S,18S)-1,6-diamino-9-(4-aminobutyl)-12-(2-carboxyethyl)-18-(4-hydroxybenzyl)-1-imino-15-isopropyl-7,10,13,16-tetraoxo-2,8,11,14,17-pentaazanonadecan-19-oic acid
InChi Key
DRCNRVYVCHHIJP-AQBORDMYSA-N
InChi Code
InChI=1S/C31H51N9O9/c1-17(2)25(29(47)39-23(30(48)49)16-18-8-10-19(41)11-9-18)40-28(46)22(12-13-24(42)43)38-27(45)21(7-3-4-14-32)37-26(44)20(33)6-5-15-36-31(34)35/h8-11,17,20-23,25,41H,3-7,12-16,32-33H2,1-2H3,(H,37,44)(H,38,45)(H,39,47)(H,40,46)(H,42,43)(H,48,49)(H4,34,35,36)/t20-,21-,22-,23-,25-/m0/s1
SMILES Code
O=C(O)[C@H](Cc1ccc(O)cc1)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)N)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 693.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Singh VK, Biswas S, Mathur KB, Haq W, Garg SK, Agarwal SS. Thymopentin and splenopentin as immunomodulators. Current status. Immunol Res. 1998;17(3):345-68. Review. PubMed PMID: 9638477. 2: Biswas S, Singh VK, Rastogi A, Sharan R, Haq W, Mathur KB, Agarwal SS. Stimulation of IL-2 production and CD2R expression by splenopentin analogs. Int J Immunopharmacol. 1997 Jun;19(6):341-5. PubMed PMID: 9467753. 3: Chatterjee-Kishore M, Agrawal S, Singh VK, Mathur KB, Haq A, Agarwal SS. Upregulation of HLA class-I gene transcription in K562 cells by analogs of splenopentin (SP-5). Biochem Mol Biol Int. 1997 Mar;41(3):521-8. Erratum in: Biochem Mol Biol Int 1997 Oct;43(2):463. PubMed PMID: 9090459. 4: Diezel W, Weber HA, Maciejewski J, Volk HD. The effect of splenopentin (DA SP-5) on in vitro myelopoiesis and on AZT-induced bone marrow toxicity. Int J Immunopharmacol. 1993 Apr;15(3):269-73. PubMed PMID: 8505137. 5: Rastogi A, Singh VK, Biswas S, Haq W, Mathur KB, Agarwal SS. Augmentation of human natural killer cells by splenopentin analogs. FEBS Lett. 1993 Feb 8;317(1-2):93-5. PubMed PMID: 8428639. 6: Simon HU, Kraul H, Schäfer R, Kilian U, Hoffmann A. Lack of effect of diacetyl-splenopentin (Berlopentin) on the pharmacokinetics of caffeine. Pharmazie. 1992 Jan;47(1):49-50. PubMed PMID: 1608985. 7: Bräuer R, Thoss K, Henzgen S, Waldmann G. Effects of the immunomodulator diacetyl-splenopentin on antigen-induced arthritis in rabbits. Agents Actions. 1992 Jan;35(1-2):96-103. PubMed PMID: 1387284. 8: Evseev VA, Davydova TV, Fomina VG, Odariuk Iu, Repke G, Oeme P, Forner K. [Splenopentin--modulator of immunological and behavioral reactions in secondary immunodeficiency state induced by experimental alcoholism]. Biull Eksp Biol Med. 1991 Jun;111(6):637-9. Russian. PubMed PMID: 1893194. 9: Simon HU, Lauterbach H, Börner A, Wachtel S. Diacetyl-splenopentin (BCH 069) did not affect the concentrations of various hormones in men. Exp Clin Endocrinol. 1990 Dec;96(3):314-6. PubMed PMID: 2083571. 10: Eckert R, Maciejewski J, Weber H, Volk HD, Diezel W, Forner K, von Baehr R. Splenopentin (DAc-SP5)--influence on engraftment and graft-vs-host reaction after non-H-2 bone marrow transplantation in mice. Exp Clin Endocrinol. 1990 Dec;96(3):307-13. PubMed PMID: 2083570. 11: Maciejewski J, Wächter M, Elstner E, Weber H, Diezel W, Seiler FR, Volk HD. Cytofluorometric and cytomorphologic analysis of human bone marrow cells derived from stromal cultures stimulated by granulocyte-macrophage colony-stimulating factor, interferon-gamma and splenopentin pentapeptide. Eur J Immunol. 1990 Jun;20(6):1209-13. PubMed PMID: 2114995. 12: Simon HU, Metzner G, Vogt WE, Piesch C, Forner K, Schlenvoigt G, Storz H, Haroske D, Jäger L. Clinical, biochemical and immunological effectiveness of diacetyl-splenopentin (BCH 069) in hay fever. Allergol Immunopathol (Madr). 1990 May-Jun;18(3):155-60. PubMed PMID: 2251976. 13: Greiner J, Miehe M, Weber H, Stoimenov A, Sönnichsen N, Diezel W. [Therapeutic use of splenopentin (DA SP-5) in patients with psoriasis arthropathica]. Dermatol Monatsschr. 1990;176(2-3):157-62. German. PubMed PMID: 2365110. 14: Gruner S, Diezel W, Strunk D, Zwirner A, Sönnichsen N, Anhalt GJ. Stimulation of the recruitment of epidermal Langerhans cells by splenopentin. Arch Dermatol Res. 1990;281(8):526-9. PubMed PMID: 2322010. 15: Weber HA, Maciejewski J, Eckert R, Schütt M, Diezel W, Volk HD. Splenopentin (DAc-SP-5) accelerates the restoration of myelopoietic and immune systems after sublethal radiation in mice. Int J Immunopharmacol. 1990;12(7):761-8. PubMed PMID: 2292457. 16: Simon HU, Reipert B, Haroske D, Forner K, Storz H. [Age-dependent sensitivity of human lymphocytes to the immunomodulating effect of bovine and human diacetyl splenopentin]. Allerg Immunol (Leipz). 1990;36(4):351-8. German. PubMed PMID: 2151503. 17: Simon HU, Metzner G, Keil E, Forner K, Vogt WE, Jäger L. Phase-I study of diacetyl-splenopentin (BCH 069). Allerg Immunol (Leipz). 1990;36(4):245-51. PubMed PMID: 1982983. 18: Eckert R, Schmidt R, Volk HD, Diezel W, Sönnichsen N, von Baehr R. Splenopentin-induced reconstitution of the immune response after total body irradiation: optimization of treatment regime. Exp Clin Endocrinol. 1989 Sep;94(1-2):223-5. PubMed PMID: 2689192. 19: Eckert R, Diezel W, Schmidt R, Forner K, Volk HD. Splenopentin (DAc SP-5)-accelerated reconstitution of antibody formation after syngeneic bone marrow transplantation. Exp Clin Endocrinol. 1989 Sep;94(1-2):219-22. PubMed PMID: 2689191. 20: Isakova OL, Sepetov NF, Forner K, Erlikh A. [A study of enzymatic hydrolysis of splenopentin and its analogs in human serum]. Bioorg Khim. 1989 Apr;15(4):453-9. Russian. PubMed PMID: 2751705.