BMS-986449 is a CELMoD molecular glue that redirects the E3 ubiquitin ligase Cereblon to interact with and induce the degradation of Helios and Eos. It was optimized to induce rapid and deep degradation of Helios and Eos in primary Treg cells with selectivity over other CELMoD neosubstrates, as assessed by global proteomic analysis of primary T cells.
MedKoo Cat#: 128838
Name: BMS-986449
CAS#: N/A
Chemical Formula: C21H21FN4O3
Exact Mass: 396.1598
Molecular Weight: 396.42
Elemental Analysis: C, 63.63; H, 5.34; F, 4.79; N, 14.13; O, 12.11
The following data is based on the product molecular weight 396.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
