BMS-986126 | CAS#1610017-20-3 | IRAK4 Inhibitor

MedKoo Cat#: 555544 | Name: BMS986126

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-986122 is a IRAK4 Inhibitor. BMS-986126 attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity. BMS-986126 inhibited TLR7- and TLR9-dependent responses using cells derived from lupus patients, suggesting that inhibition of IRAK4 has the potential for therapeutic benefit in treating lupus.

Chemical Structure

BMS986126

CAS#1610017-20-3

Theoretical Analysis

MedKoo Cat#: 555544

Name: BMS986126

CAS#: 1610017-20-3

Chemical Formula: C16H15BrClNO3S2

Exact Mass: 446.9365

Molecular Weight: 448.77

Elemental Analysis: C, 42.82; H, 3.37; Br, 17.80; Cl, 7.90; N, 3.12; O, 10.70; S, 14.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

BMS-986126; BMS 986126; BMS986126;

IUPAC/Chemical Name

(R)-6-((1,6-naphthyridin-2-yl)amino)-4-(cyclopropylamino)-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide

InChi Key

PXAWSYHMHMFXBD-GOSISDBHSA-N

InChi Code

InChI=1S/C22H25FN6O2/c1-22(2,31)18(23)12-26-21(30)15-11-25-20(9-17(15)27-14-4-5-14)29-19-6-3-13-10-24-8-7-16(13)28-19/h3,6-11,14,18,31H,4-5,12H2,1-2H3,(H,26,30)(H2,25,27,28,29)/t18-/m1/s1

SMILES Code

O=C(NC[C@@H](F)C(C)(C)O)C1=CN=C(NC2=CC=C(C=NC=C3)C3=N2)C=C1NC4CC4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Note structure was from Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors Marian C. Bryan*Joy DrobnickAlberto GobbiAleksandr KolesnikovYongsheng ChenNaomi RajapaksaChudi NdubakuJianwen FengWilly ChangRoss FrancisChristine YuEdna F. ChooKevin DeMentYingqing RanLe AnClaire EmsonZhiyu HuangSwathi Sujatha-BhaskarHans BrightbillAntonio DiPasqualeJonathan MaherJohn WaiBrent S. McKenziePatrick J. LupardusAli A. ZarrinJames R. Kiefer Journal of Medicinal Chemistry, Articles ASAP (As Soon As Publishable)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 448.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ruepp S, Janovitz E, Brodie T, White R, Santella J, Hynes J, Carman J, Pan D, Wu Y, Hanumegowda U, Gemzik B, Megill J, DiPiero J, Drexler D, Su CC, Hageman M. Assessing the risk of drug crystallization in vivo. J Pharmacol Toxicol Methods. 2019 Mar - Apr;96:1-8. doi: 10.1016/j.vascn.2018.12.003. Epub 2018 Dec 13. PubMed PMID: 30553974. 2: Dudhgaonkar S, Ranade S, Nagar J, Subramani S, Prasad DS, Karunanithi P, Srivastava R, Venkatesh K, Selvam S, Krishnamurthy P, Mariappan TT, Saxena A, Fan L, Stetsko DK, Holloway DA, Li X, Zhu J, Yang WP, Ruepp S, Nair S, Santella J, Duncia J, Hynes J, McIntyre KW, Carman JA. Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity. J Immunol. 2017 Feb 1;198(3):1308-1319. doi: 10.4049/jimmunol.1600583. Epub 2016 Dec 21. PubMed PMID: 28003376; PubMed Central PMCID: PMC5253435.