Radamide | 1166398-85-1 | Grp94 inhibitor

MedKoo Cat#: 555194 | Name: Radamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Radamide is a Grp94 inhibitor.

Chemical Structure

Radamide

CAS#1166398-85-1

Theoretical Analysis

MedKoo Cat#: 555194

Name: Radamide

CAS#: 1166398-85-1

Chemical Formula: C18H18ClNO8

Exact Mass: 411.0721

Molecular Weight: 411.79

Elemental Analysis: C, 52.50; H, 4.41; Cl, 8.61; N, 3.40; O, 31.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Radamide

IUPAC/Chemical Name

ethyl 3-chloro-2-(2-((2,5-dihydroxy-4-methoxyphenyl)amino)-2-oxoethyl)-4,6-dihydroxybenzoate

InChi Key

RULSXWFZXUOCOD-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H18ClNO8/c1-3-28-18(26)16-8(17(19)13(24)6-12(16)23)4-15(25)20-9-5-11(22)14(27-2)7-10(9)21/h5-7,21-24H,3-4H2,1-2H3,(H,20,25)

SMILES Code

O=C(OCC)C1=C(O)C=C(O)C(Cl)=C1CC(NC2=CC(O)=C(OC)C=C2O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 411.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Crowley VM, Khandelwal A, Mishra S, Stothert AR, Huard DJ, Zhao J, Muth A, Duerfeldt AS, Kizziah JL, Lieberman RL, Dickey CA, Blagg BS. Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold. J Med Chem. 2016 Apr 14;59(7):3471-88. doi: 10.1021/acs.jmedchem.6b00085. Epub 2016 Apr 4. PubMed PMID: 27003516; PubMed Central PMCID: PMC4979570. 2: Muth A, Crowley V, Khandelwal A, Mishra S, Zhao J, Hall J, Blagg BS. Development of radamide analogs as Grp94 inhibitors. Bioorg Med Chem. 2014 Aug 1;22(15):4083-98. doi: 10.1016/j.bmc.2014.05.075. Epub 2014 Jun 12. PubMed PMID: 25027801; PubMed Central PMCID: PMC4142655. 3: Hadden MK, Blagg BS. Synthesis and evaluation of radamide analogues, a chimera of radicicol and geldanamycin. J Org Chem. 2009 Jul 3;74(13):4697-704. doi: 10.1021/jo900278g. PubMed PMID: 19492825; PubMed Central PMCID: PMC2844856. 4: Immormino RM, Metzger LE 4th, Reardon PN, Dollins DE, Blagg BS, Gewirth DT. Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design. J Mol Biol. 2009 May 22;388(5):1033-42. doi: 10.1016/j.jmb.2009.03.071. Epub 2009 Apr 8. PubMed PMID: 19361515; PubMed Central PMCID: PMC2692672. 5: Clevenger RC, Blagg BS. Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide. Org Lett. 2004 Nov 25;6(24):4459-62. PubMed PMID: 15548050.