Paenibacterin A1 | CAS#1400801-10-6 | Antibiotic

MedKoo Cat#: 208481 | Name: Paenibacterin A1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Paenibacterin A1 is a broad-spectrum, cationic cyclic lipodepsipeptide antibiotic isolated from Paenibacillus thiaminolyticus

Chemical Structure

Paenibacterin A1

CAS#1400801-10-6

Theoretical Analysis

MedKoo Cat#: 208481

Name: Paenibacterin A1

CAS#: 1400801-10-6

Chemical Formula: C80H146N16O17

Exact Mass: 1603.1052

Molecular Weight: 1604.14

Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: 1604.1430 Elemental Analysis: C, 59.90; H, 9.17; N, 13.97; O, 16.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PaenibacterinA1, PA1

IUPAC/Chemical Name

N-((R)-5-Amino-1-(((S)-1-(((3S,6S,9S,12R,13S,16S,19S,22S,25R,28R,31S,36aS)-6,25-bis(4-aminobutyl)-16-(3-aminopropyl)-9,31-di((S)-sec-butyl)-19,28-bis(hydroxymethyl)-3,22-diisopropyl-12-methyl-1,4,7,10,14,17,20,23,26,29,32-undecaoxotetratriacontahydro-12H-pyrrolo[2,1-l][1]oxa[4,7,10,13,16,19,22,25,28]nonaazacyclotetratriacontin-13-yl)amino)-3-methyl-1-oxobutan-2-yl)amino)-1-oxopentan-2-yl)pentadecanamide

InChi Key

JTXATJWSQWVPAX-NOSAKYFSSA-N

InChi Code

InChI=1S/C80H146N16O17/c1-13-16-17-18-19-20-21-22-23-24-25-26-39-62(100)85-55(37-32-43-84)71(103)90-65(50(8)9)78(110)95-68-53(12)113-80(112)67(52(11)15-3)94-72(104)57(36-28-30-41-82)87-77(109)64(49(6)7)92-75(107)60-38-33-44-96(60)79(111)66(51(10)14-2)93-74(106)59(47-98)89-70(102)56(35-27-29-40-81)86-76(108)63(48(4)5)91-73(105)58(46-97)88-69(101)54(34-31-42-83)45-61(68)99/h48-60,63-68,97-98H,13-47,81-84H2,1-12H3,(H,85,100)(H,86,108)(H,87,109)(H,88,101)(H,89,102)(H,90,103)(H,91,105)(H,92,107)(H,93,106)(H,94,104)(H,95,110)/t51-,52-,53+,54-,55+,56+,57-,58-,59+,60-,63-,64-,65-,66-,67-,68-/m0/s1

SMILES Code

CCCCCCCCCCCCCCC(N[C@H](CCCN)C(N[C@@H](C(C)C)C(N[C@@H]1C(C[C@H](CCCN)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@H](CCCCN)C(N[C@H](CO)C(N[C@@H]([C@@H](C)CC)C(N2[C@](CCC2)([H])C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(O[C@@H]1C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,604.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Noden M, Goodyear J, Taylor SD. Effect of Lipid Length and Cationic Residues on the Antibacterial and Hemolytic Activities of Paenibacterin. ACS Infect Dis. 2022 Sep 9. doi: 10.1021/acsinfecdis.2c00157. Epub ahead of print. PMID: 36083849.