Synonym
Bax Inhibitor Peptide V5; BIP V5; VPMLK
IUPAC/Chemical Name
L-valyl-L-prolyl-L-methionyl-L-leucyl-L-lysine
InChi Key
NHMUTADCTDDWPV-YFNVTMOMSA-N
InChi Code
InChI=1S/C27H50N6O6S/c1-16(2)15-20(24(35)31-19(27(38)39)9-6-7-12-28)32-23(34)18(11-14-40-5)30-25(36)21-10-8-13-33(21)26(37)22(29)17(3)4/h16-22H,6-15,28-29H2,1-5H3,(H,30,36)(H,31,35)(H,32,34)(H,38,39)/t18-,19-,20-,21-,22-/m0/s1
SMILES Code
NCCCC[C@@H](C(O)=O)NC([C@H](CC(C)C)NC([C@H](CCSC)NC([C@H]1N(C([C@H](C(C)C)N)=O)CCC1)=O)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
586.79
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yoshida, T., Tomioka, I., Nagahara, T., et al. Bax-inhibiting peptide derived from mouse and rat Ku70. Biochem. Biophys. Res. Commun. 321(4), 961-966 (2004).
2: Rivas-Carrillo, J.D., Soto-Gutierrez, A., Navarro-Alvarez, N., et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes 56(5), 1259-1267 (2007).
3: Wang, X., Han, W., Du, X., et al. Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injury. Stroke 41(9), 2050-2055 (2010).
