MedKoo Cat#: 561892 | Name: MMV665852
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MMV665852 is an antischistosomal agent. It has been shown to inhibit worm viability in vitro and reduce worm burden in S. mansoni-infected mice.

Chemical Structure

MMV665852
CAS#4300-43-0

Theoretical Analysis

MedKoo Cat#: 561892

Name: MMV665852

CAS#: 4300-43-0

Chemical Formula: C13H8Cl4N2O

Exact Mass: 347.9391

Molecular Weight: 350.02

Elemental Analysis: C, 44.61; H, 2.30; Cl, 40.51; N, 8.00; O, 4.57

Price and Availability

Size Price Availability Quantity
1g USD 350.00 2 Weeks
5g USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
MMV665852; MMV-665852; MMV 665852;
IUPAC/Chemical Name
1,3-Bis(3,4-dichlorophenyl)urea
InChi Key
ZDPIZPXVHVYTOK-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H8Cl4N2O/c14-9-3-1-7(5-11(9)16)18-13(20)19-8-2-4-10(15)12(17)6-8/h1-6H,(H2,18,19,20)
SMILES Code
O=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=CC=C(Cl)C(Cl)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
MMV665852 is an antischistosomal agent.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 350.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Cowan N, Dätwyler P, Ernst B, Wang C, Vennerstrom JL, Spangenberg T, Keiser J. Activities of N,N'-Diarylurea MMV665852 analogs against Schistosoma mansoni. Antimicrob Agents Chemother. 2015 Apr;59(4):1935-41. doi: 10.1128/AAC.04463-14. Epub 2015 Jan 12. PubMed PMID: 25583726; PubMed Central PMCID: PMC4356791.