MNI-444 | CAS#1974301-94-4 | radiotracer

MedKoo Cat#: 584723 | Name: MNI-444

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MNI-444 is a PET radiotracer for adenosine 2A receptors.

Chemical Structure

MNI-444

CAS#1974301-94-4

Theoretical Analysis

MedKoo Cat#: 584723

Name: MNI-444

CAS#: 1974301-94-4

Chemical Formula: C24H26FN9O2

Exact Mass: 491.2193

Molecular Weight: 491.53

Elemental Analysis: C, 58.65; H, 5.33; F, 3.87; N, 25.65; O, 6.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

MNI-444; MNI444; MNI 444

IUPAC/Chemical Name

7H-Pyrazolo(4,3-E)(1,2,4)triazolo(1,5-C)pyrimidin-5-amine, 7-(2-(4-(4-(2-fluoroethoxy)phenyl)-1-piperazinyl)ethyl)-2-(2-furanyl)-

InChi Key

QKAGUODENRFONW-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H26FN9O2/c25-7-15-35-18-5-3-17(4-6-18)32-11-8-31(9-12-32)10-13-33-22-19(16-27-33)23-28-21(20-2-1-14-36-20)30-34(23)24(26)29-22/h1-6,14,16H,7-13,15H2,(H2,26,29)

SMILES Code

NC1=NC(N(CCN2CCN(C3=CC=C(OCCF)C=C3)CC2)N=C4)=C4C5=NC(C6=CC=CO6)=NN15

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 491.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Barret O, Hannestad J, Vala C, Alagille D, Tavares A, Laruelle M, Jennings D, Marek K, Russell D, Seibyl J, Tamagnan G. Characterization in humans of 18F-MNI-444, a PET radiotracer for brain adenosine 2A receptors. J Nucl Med. 2015 Apr;56(4):586-91. doi: 10.2967/jnumed.114.152546. Epub 2015 Feb 19. PubMed PMID: 25698783. 2: Barret O, Hannestad J, Alagille D, Vala C, Tavares A, Papin C, Morley T, Fowles K, Lee H, Seibyl J, Tytgat D, Laruelle M, Tamagnan G. Adenosine 2A receptor occupancy by tozadenant and preladenant in rhesus monkeys. J Nucl Med. 2014 Oct;55(10):1712-8. doi: 10.2967/jnumed.114.142067. Epub 2014 Jul 31. PubMed PMID: 25082853.