MMV665916 | CAS#896356-25-5 | Antimalarial agent

MedKoo Cat#: 466207 | Name: MMV665916

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MMV665916 is a novel antimalarial agent, targeting P. falciparum farnesyltransferase PfFT, showing remarkable growth inhibition with EC50 value of 0.4 µM and presenting good selectivity index (SI > 250).

Chemical Structure

MMV665916

CAS#896356-25-5

Theoretical Analysis

MedKoo Cat#: 466207

Name: MMV665916

CAS#: 896356-25-5

Chemical Formula: C19H19N3O4

Exact Mass: 353.1376

Molecular Weight: 353.38

Elemental Analysis: C, 64.58; H, 5.42; N, 11.89; O, 18.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

MMV665916; MMV 665916; MMV-665916;

IUPAC/Chemical Name

3-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(2-methoxybenzyl)propanamide

InChi Key

GONCPXNUBXWDEU-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H19N3O4/c1-26-16-9-5-2-6-13(16)12-20-17(23)10-11-22-18(24)14-7-3-4-8-15(14)21-19(22)25/h2-9H,10-12H2,1H3,(H,20,23)(H,21,25)

SMILES Code

O=C(NCC1=CC=CC=C1OC)CCN2C(NC3=C(C=CC=C3)C2=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 353.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mourot L, Schmitt M, Mouray E, Spichty M, Florent I, Albrecht S. Structure- activity relationship and molecular modelling studies of quinazolinedione derivatives MMV665916 as potential antimalarial agent. Bioorg Med Chem. 2021 Dec 1;51:116513. doi: 10.1016/j.bmc.2021.116513. Epub 2021 Nov 12. PMID: 34798379.