MedKoo Cat#: 527012 | Name: MOPS-Na
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MOPS-Na is a novel stabilizer as buffer for the native structure of BSA against thermal denaturation.

Chemical Structure

MOPS-Na
MOPS-Na
CAS#71119-22-7

Theoretical Analysis

MedKoo Cat#: 527012

Name: MOPS-Na

CAS#: 71119-22-7

Chemical Formula: C7H14NNaO4S

Exact Mass: 231.0541

Molecular Weight: 231.24

Elemental Analysis: C, 36.36; H, 6.10; N, 6.06; Na, 9.94; O, 27.67; S, 13.86

Price and Availability

Size Price Availability Quantity
25g USD 200.00
100g USD 350.00
250g USD 650.00
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Related CAS #
No Data
Synonym
MOPS-Na
IUPAC/Chemical Name
4-Morpholinepropanesulfonic acid sodium salt
InChi Key
MWEMXEWFLIDTSJ-UHFFFAOYSA-M
InChi Code
InChI=1S/C7H15NO4S.Na/c9-13(10,11)7-1-2-8-3-5-12-6-4-8;/h1-7H2,(H,9,10,11);/q;+1/p-1
SMILES Code
O=S(CCCN1CCOCC1)([O-])=O.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
MOPS sodium salt is commonly used as a buffering agent in biology.
In vitro activity:
Study of coxsackievirus B3 strain 28 (CVB3/28) stability using MOPS to improve buffering in the experimental medium revealed that MOPS (3-morpholinopropane-1-sulfonic acid) increased CVB3 stability and the effect was concentration dependent. Computer-simulated molecular docking showed that MOPS can occupy the hydrophobic pocket in capsid protein VP1 where the sulfonic acid head group can form ionic and hydrogen bonds with Arg95 and Asn211 near the pocket opening. Reference: Virology. 2017 Jan 15;501:183-187. https://pubmed.ncbi.nlm.nih.gov/27940223/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 231.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Carson SD, Hafenstein S, Lee H. MOPS and coxsackievirus B3 stability. Virology. 2017 Jan 15;501:183-187. doi: 10.1016/j.virol.2016.12.002. Epub 2016 Dec 8. PMID: 27940223; PMCID: PMC5218500. 2. Schmidt J, Wei R, Oeser T, Belisário-Ferrari MR, Barth M, Then J, Zimmermann W. Effect of Tris, MOPS, and phosphate buffers on the hydrolysis of polyethylene terephthalate films by polyester hydrolases. FEBS Open Bio. 2016 Jul 20;6(9):919-27. doi: 10.1002/2211-5463.12097. PMID: 27642555; PMCID: PMC5011490.
In vitro protocol:
1. Carson SD, Hafenstein S, Lee H. MOPS and coxsackievirus B3 stability. Virology. 2017 Jan 15;501:183-187. doi: 10.1016/j.virol.2016.12.002. Epub 2016 Dec 8. PMID: 27940223; PMCID: PMC5218500. 2. Schmidt J, Wei R, Oeser T, Belisário-Ferrari MR, Barth M, Then J, Zimmermann W. Effect of Tris, MOPS, and phosphate buffers on the hydrolysis of polyethylene terephthalate films by polyester hydrolases. FEBS Open Bio. 2016 Jul 20;6(9):919-27. doi: 10.1002/2211-5463.12097. PMID: 27642555; PMCID: PMC5011490.
In vivo protocol:
TBD
1: Gupta BS, Taha M, Lee MJ. Buffers more than buffering agent: introducing a new class of stabilizers for the protein BSA. Phys Chem Chem Phys. 2015 Jan 14;17(2):1114-33. doi: 10.1039/c4cp04663c. Epub 2014 Nov 21. PubMed PMID: 25415385. 2: Shimura K, Waki T, Okada M, Toda T, Kimoto I, Kasai K. Analysis of protein-protein interactions with a multi-capillary electrophoresis instrument. Electrophoresis. 2006 May;27(10):1886-94. PubMed PMID: 16703627. 3: Porter DJ, Short SA. Yeast orotidine-5'-phosphate decarboxylase: steady-state and pre-steady-state analysis of the kinetic mechanism of substrate decarboxylation. Biochemistry. 2000 Sep 26;39(38):11788-800. PubMed PMID: 10995247.