Mebrofenin | CAS#78266-06-5

MedKoo Cat#: 535050 | Name: Mebrofenin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mebrofenin, also known as SQ 26962, is a useful ligand to binding radioactive metal ions. Tc-99m mebrofenin is a diagnostic agent for hepatobiliary imaging. Tc-99m Mebrofenin is the radiopharmaceutical of choice for the evaluation of hepatic function. 99m Tc-Mebrofenin HBS has a significant role in the evaluation of PCS.

Chemical Structure

Mebrofenin

CAS#78266-06-5

Theoretical Analysis

MedKoo Cat#: 535050

Name: Mebrofenin

CAS#: 78266-06-5

Chemical Formula: C15H19BrN2O5

Exact Mass: 386.0477

Molecular Weight: 387.23

Elemental Analysis: C, 46.53; H, 4.95; Br, 20.63; N, 7.23; O, 20.66

Price and Availability

Size	Price	Availability
5mg	USD 350.00	2 Weeks
25mg	USD 550.00	2 Weeks
100mg	USD 750.00	2 Weeks

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Related CAS #

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Synonym

Mebrofenin; SQ 26962; SQ 26962; SQ 26962;

IUPAC/Chemical Name

Glycine, N-(2-((3-bromo-2,4,6-trimethylphenyl)amino)-2-oxoethyl)-N-(carboxymethyl)-

InChi Key

MHPZZZZLAQGTHT-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H19BrN2O5/c1-8-4-9(2)15(10(3)14(8)16)17-11(19)5-18(6-12(20)21)7-13(22)23/h4H,5-7H2,1-3H3,(H,17,19)(H,20,21)(H,22,23)

SMILES Code

O=C(O)CN(CC(NC1=C(C)C=C(C)C(Br)=C1C)=O)CC(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Chronic viral hepatitis B and C infections are one of the leading causes of chronic liver impairment, resulting in liver fibrosis and liver cirrhosis. An early diagnosis with accurate liver fibrosis staging leads to a proper diagnosis, thus tailoring correct treatment. Both invasive and noninvasive techniques are used in the diagnosis and staging of chronic liver impairment. Those techniques include liver biopsy, multiple serological markers (as either single tests or combined panels), and imaging examinations, such as ultrasound or magnetic resonance elastography. Nuclear medicine probes may also be employed in staging liver fibrosis

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 387.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Smet H, Martin D, Uldry E, Duran R, Girardet R, Schaefer N, Prior JO, Denys A, Halkic N, Demartines N, Melloul E. Tc-99m mebrofenin hepatobiliary scintigraphy to assess future liver remnant function before major liver surgery. J Surg Oncol. 2023 Aug 28. doi: 10.1002/jso.27426. Epub ahead of print. PMID: 37638473. 2: Arntz PJW, Deroose CM, Marcus C, Sturesson C, Panaro F, Erdmann J, Manevska N, Moadel R, de Geus-Oei LF, Bennink RJ. Joint EANM/SNMMI/IHPBA procedure guideline for [99mTc]Tc-mebrofenin hepatobiliary scintigraphy SPECT/CT in the quantitative assessment of the future liver remnant function. HPB (Oxford). 2023 Jun 2:S1365-182X(23)00546-4. doi: 10.1016/j.hpb.2023.06.001. Epub ahead of print. PMID: 37394397. 3: Czibor S, Bibok A, Horváthy D, Fábián K, Györke T. Radioembolization Planning With Dual-Isotope Acquisition of 166 Ho-Labeled Microparticles and 99m Tc- Mebrofenin. Clin Nucl Med. 2023 Aug 1;48(8):719-721. doi: 10.1097/RLU.0000000000004732. Epub 2023 Jun 8. PMID: 37290424; PMCID: PMC10317298. 4: Jocius D, Vajauskas D, Samuilis A, Mikelis K, Jokubauskiene S, Strupas K, Tamosiunas AE. Assessing Liver Fibrosis Using 2D-SWE Liver Ultrasound Elastography and Dynamic Liver Scintigraphy with 99mTc-mebrofenin: A Comparative Prospective Single-Center Study. Medicina (Kaunas). 2023 Feb 28;59(3):479. doi: 10.3390/medicina59030479. PMID: 36984480; PMCID: PMC10055019. 5: Pirot C, Peyronnet D, Vigne J. Optimised quality control method for determination of the radiochemical purity of [99mTc]Tc-mebrofenin and [99mTc]Tc-etifenin in a clinical context. Eur J Hosp Pharm. 2023 Jan 23:ejhpharm-2022-003512. doi: 10.1136/ejhpharm-2022-003512. Epub ahead of print. PMID: 36690417. 6: Jocius D, Vajauskas D, Mikelis K, Jokubauskiene S, Jakutiene J, Strupas K, Tamosiunas AE. Quantitative Assessment of Liver Impairment in Chronic Viral Hepatitis with [99mTc]Tc-Mebrofenin: A Noninvasive Attempt to Stage Viral Hepatitis-Associated Liver Fibrosis. Medicina (Kaunas). 2022 Sep 23;58(10):1333. doi: 10.3390/medicina58101333. PMID: 36295494; PMCID: PMC9612220. 7: Wang Q, Brismar TB, Gilg S, Jonas E, Nilsson H, Tzortzakakis A, Isaksson B, Axelsson R, Sparrelid E. Multimodal perioperative assessment of liver function and volume in patients undergoing hepatectomy for colorectal liver metastasis: a comparison of the indocyanine green retention test, 99mTc mebrofenin hepatobiliary scintigraphy and gadoxetic acid enhanced MRI. Br J Radiol. 2022 Oct 1;95(1139):20220370. doi: 10.1259/bjr.20220370. Epub 2022 Oct 10. PMID: 36113499; PMCID: PMC9793491. 8: Sowmya SD, Gupta A, Narayan ML, Chauhan U, Jain J, Singla T, Chennatt JJ. Role of 99m Tc-Mebrofenin Hepatobiliary Scintigraphy in the Diagnosis of Post Cholecystectomy Syndrome. World J Nucl Med. 2022 Aug 16;21(3):231-235. doi: 10.1055/s-0042-1751038. PMID: 36060090; PMCID: PMC9436510. 9: Sánchez-Vera Y, Aguilera-Hernández E, Cardoza-Ochoa DR, González-Díaz JI. Diagnosis of Traumatic Bronchobiliary Fistula With Late 99m Tc-Mebrofenin SPECT/CT. Clin Nucl Med. 2022 Dec 1;47(12):e752-e753. doi: 10.1097/RLU.0000000000004334. Epub 2022 Jul 15. PMID: 35835115. 10: Marie S, Hernández-Lozano I, Le Vée M, Breuil L, Saba W, Goislard M, Goutal S, Truillet C, Langer O, Fardel O, Tournier N. Pharmacokinetic Imaging Using 99mTc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats. Pharmaceuticals (Basel). 2022 Mar 24;15(4):392. doi: 10.3390/ph15040392. PMID: 35455390; PMCID: PMC9028474. 11: Uña-Gorospe JA. Determination of the segmental hepatic clearance rate of 99mTc-mebrofenin and its application in the functional assessment of future liver remnant after liver resection. Rev Esp Med Nucl Imagen Mol (Engl Ed). 2021 Nov-Dec;40(6):385-396. doi: 10.1016/j.remnie.2021.09.001. Epub 2021 Oct 15. PMID: 34663555. 12: Meristoudis G, Ilias I, Zaromytidou E, Alevroudis E, Notopoulos A. Cholethorax with biliopleural communication detected on [99mTc]mebrofenin hepatobiliary scintigraphy. Nucl Med Rev Cent East Eur. 2021;24(2):124-125. doi: 10.5603/NMR.2021.0031. PMID: 34382684. 13: Guiu B, Deshayes E, Panaro F, Sanglier F, Cusumano C, Herrerro A, Sgarbura O, Molinari N, Quenet F, Cassinotto C. 99mTc-mebrofenin hepatobiliary scintigraphy and volume metrics before liver preparation: correlations and discrepancies in non-cirrhotic patients. Ann Transl Med. 2021 May;9(9):795. doi: 10.21037/atm-20-7372. PMID: 34268408; PMCID: PMC8246210. 14: Marie S, Hernández-Lozano I, Breuil L, Truillet C, Hu S, Sparreboom A, Tournier N, Langer O. Imaging-Based Characterization of a Slco2b1(-/-) Mouse Model Using [11C]Erlotinib and [99mTc]Mebrofenin as Probe Substrates. Pharmaceutics. 2021 Jun 21;13(6):918. doi: 10.3390/pharmaceutics13060918. PMID: 34205780; PMCID: PMC8233734. 15: Marie S, Hernández-Lozano I, Langer O, Tournier N. Repurposing 99mTc-Mebrofenin as a Probe for Molecular Imaging of Hepatocyte Transporters. J Nucl Med. 2021 Aug 1;62(8):1043-1047. doi: 10.2967/jnumed.120.261321. Epub 2021 Mar 5. PMID: 33674399. 16: Serenari M, Calabrò D, Bonfiglioli R, Fanti S, Ravaioli M. 99mTc-Mebrofenin Hepatobiliary Scintigraphy Combined With SPECT/CT to Assess Liver Function in Heterotopic Segmental Liver Transplantation in the Splenic Fossa. Clin Nucl Med. 2021 Jun 1;46(6):e332-e335. doi: 10.1097/RLU.0000000000003521. PMID: 33577197. 17: Piron L, Deshayes E, Cassinotto C, Quenet F, Panaro F, Hermida M, Allimant C, Assenat E, Pageaux GP, Molinari N, Guiu B. Deportalization, Venous Congestion, Venous Deprivation: Serial Measurements of Volumes and Functions on Morphofunctional 99mTc-Mebrofenin SPECT-CT. Diagnostics (Basel). 2020 Dec 23;11(1):12. doi: 10.3390/diagnostics11010012. PMID: 33374810; PMCID: PMC7823835. 18: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Technetium Tc 99m Mebrofenin. 2020 Oct 19. PMID: 29999776. 19: Mattay GS, O'Leary C, Dubroff JG, Pantel AR. 99mTc-Mebrofenin SPECT/CT in Hepatic Infarction. Clin Nucl Med. 2021 Jan;46(1):e8-e10. doi: 10.1097/RLU.0000000000003312. PMID: 33031234. 20: Truant S, Baillet C, Gnemmi V, Fulbert M, Turpin A, Dardenne S, Leteurtre E, El Amrani M, Dharancy S, Dubuquoy L, Huglo D, Chesné C, Pruvot FR. The Impact of Modern Chemotherapy and Chemotherapy-Associated Liver Injuries (CALI) on Liver Function: Value of 99mTc-Labelled-Mebrofenin SPECT-Hepatobiliary Scintigraphy. Ann Surg Oncol. 2021 Apr;28(4):1959-1969. doi: 10.1245/s10434-020-08988-4. Epub 2020 Aug 24. PMID: 32833150.