DJ-89 is a sEH Inhibitor (IC50: 0.51 nM), DJ-89 demonstrated additional interactions with sEH compared to TPPU, and uniquely enhanced anti-inflammatory factors, including EET levels and IL-10, a capability not observed with EC5026. Moreover, DJ-89 showed excellent pharmacokinetics and safety, positioning it as a promising candidate for treating both acute and chronic inflammatory diseases, including rheumatoid arthritis, leveraging phenylacylpiperidine scaffolds in sEH-targeted therapies.
MedKoo Cat#: 128794
Name: DJ-89
CAS#: N/A
Chemical Formula: C24H28F3N3O5
Exact Mass: 495.1981
Molecular Weight: 495.50
Elemental Analysis: C, 58.18; H, 5.70; F, 11.50; N, 8.48; O, 16.14
The following data is based on the product molecular weight 495.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
