Ioxitalamic Acid | CAS#28179-44-4 | contrast medium

MedKoo Cat#: 561634 | Name: Ioxitalamic Acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ioxitalamic Acid, also known as Telebrix or Vasobrix, is a medical contrast medium. It enhances the contrast of structures or fluids within the body in medical imaging.

Chemical Structure

Ioxitalamic Acid

CAS#28179-44-4

Theoretical Analysis

MedKoo Cat#: 561634

Name: Ioxitalamic Acid

CAS#: 28179-44-4

Chemical Formula: C12H11I3N2O5

Exact Mass: 643.7802

Molecular Weight: 643.94

Elemental Analysis: C, 22.38; H, 1.72; I, 59.12; N, 4.35; O, 12.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Ioxitalamic Acid; Telebrix; Vasobrix;

IUPAC/Chemical Name

3-Acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodobenzoic acid

InChi Key

OLAOYPRJVHUHCF-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H11I3N2O5/c1-4(19)17-10-8(14)5(11(20)16-2-3-18)7(13)6(9(10)15)12(21)22/h18H,2-3H2,1H3,(H,16,20)(H,17,19)(H,21,22)

SMILES Code

O=C(O)C1=C(I)C(C(NCCO)=O)=C(I)C(NC(C)=O)=C1I

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Ioxitalamic Acid, also known as Telebrix or Vasobrix, is a medical contrast medium.

In vitro activity:

Following treatment for 48 h, the highly toxic radiocontrast agent, ioxitalamate, exerted cytotoxic effects on the HK-2 cells in a concentration-dependent manner, as shown by MTT assay. The half maximal inhibitory concentration (IC50) was found to be approximately 30 mg/ml. Flow cytometry also revealed a marked increase in the number of apoptotic cells following exposure to ioxitalamate. In addition, the number of necrotic, but not necroptotic cells was increased. Reference: Int J Mol Med. 2016 Jan;37(1):83-91. https://pubmed.ncbi.nlm.nih.gov/26573558/

In vivo activity:

The administration of TBX (ioxitalamic acid) induced a significant (p < 0.001) increase in serum urea and creatinine levels of treated rats with respect to the control. Reference: Antioxidants (Basel). 2021 Feb 2;10(2):221. https://pubmed.ncbi.nlm.nih.gov/33540787/

Preparing Stock Solutions

The following data is based on the product molecular weight 643.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Huang YT, Chen YY, Lai YH, Cheng CC, Lin TC, Su YS, Liu CH, Lai PC. Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro. Int J Mol Med. 2016 Jan;37(1):83-91. doi: 10.3892/ijmm.2015.2404. Epub 2015 Nov 9. PMID: 26573558; PMCID: PMC4687441. 2. El-Garawani I, Hassab El-Nabi S, El Kattan A, Sallam A, Elballat S, Abou-Ghanima S, El Azab IH, R El-Seedi H, A M Khalifa S, El-Shamy S. The Ameliorative Role of Acacia senegal Gum against the Oxidative Stress and Genotoxicity Induced by the Radiographic Contrast Medium (Ioxitalamate) in Albino Rats. Antioxidants (Basel). 2021 Feb 2;10(2):221. doi: 10.3390/antiox10020221. PMID: 33540787; PMCID: PMC7912984.

In vitro protocol:

In vivo protocol:

1. El-Garawani I, Hassab El-Nabi S, El Kattan A, Sallam A, Elballat S, Abou-Ghanima S, El Azab IH, R El-Seedi H, A M Khalifa S, El-Shamy S. The Ameliorative Role of Acacia senegal Gum against the Oxidative Stress and Genotoxicity Induced by the Radiographic Contrast Medium (Ioxitalamate) in Albino Rats. Antioxidants (Basel). 2021 Feb 2;10(2):221. doi: 10.3390/antiox10020221. PMID: 33540787; PMCID: PMC7912984.

1: Roux FA, Deschamps JY. Inadvertent intrathecal administration of ionic contrast medium to a dog. Vet Radiol Ultrasound. 2007 Sep-Oct;48(5):414-7. Review. PubMed PMID: 17899973. 2: van der Leede H, Jorens PG, Parizel P, Cras P. Inadvertent intrathecal use of ionic contrast agent. Eur Radiol. 2002 Dec;12 Suppl 3:S86-93. Epub 2002 Jun 4. Review. PubMed PMID: 12522612. 3: Sergeev PV, Sviridov NK, Poliaev IuA, Shimanovskiĭ NL. [Diagnostic effectiveness and safety of currently available X-ray contrast media]. Vestn Rentgenol Radiol. 1999 Nov-Dec;(6):45-9. Review. Russian. PubMed PMID: 10714233.