CJOC42 binds to and inhibits gankyrin activity in a dose-dependent manner. Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. Cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin, and it restores p53-dependent transcription and sensitivity to DNA damage.
MedKoo Cat#: 561522
Name: CJOC42
CAS#: 2171519-89-2
Chemical Formula: C20H21N3O5S
Exact Mass: 415.1202
Molecular Weight: 415.46
Elemental Analysis: C, 57.82; H, 5.10; N, 10.11; O, 19.25; S, 7.72
The following data is based on the product molecular weight 415.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
