Aldosterone synthase (AS) inhibitors (ASI) attenuate the production of aldosterone directly and have been proposed as an alternative to mineralocorticoid receptor antagonists for blocking the pathologic effects of excess aldosterone. BI 689648 is a Highly Selective Aldosterone Synthase Inhibitor (in vitro IC50, 2 nM). BI 689648 represents an important step forward toward developing ASIs with greater potential for clinical success in cardiometabolic diseases.
MedKoo Cat#: 530425
Name: BI-689648
CAS#: 1633009-87-6
Chemical Formula: C16H18N4O2
Exact Mass: 298.1430
Molecular Weight: 298.35
Elemental Analysis: C, 64.41; H, 6.08; N, 18.78; O, 10.73
The following data is based on the product molecular weight 298.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
