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MedKoo Cat#: 462441 | Name: SNT-207858 free base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist.

Chemical Structure

SNT-207858 free base
SNT-207858 free base
CAS#1104662-66-9

Theoretical Analysis

MedKoo Cat#: 462441

Name: SNT-207858 free base

CAS#: 1104662-66-9

Chemical Formula: C32H43Cl2N5O3

Exact Mass: 615.2743

Molecular Weight: 616.63

Elemental Analysis: C, 62.33; H, 7.03; Cl, 11.50; N, 11.36; O, 7.78

Price and Availability

Size Price Availability Quantity
5mg USD 750.00 2 Weeks
10mg USD 1,250.00 2 Weeks
50mg USD 3,000.00 2 Weeks
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Related CAS #
1104080-42-3
Synonym
SNT-207858 free base; SNT207858 free base; SNT 207858 free base
IUPAC/Chemical Name
N-((R)-3-(2,4-dichlorophenyl)-1-oxo-1-(4-(3-((R)-2-(pyrrolidin-1-yl)butoxy)pyridin-2-yl)piperidin-1-yl)propan-2-yl)pyrrolidine-1-carboxamide
InChi Key
GNSVFEJLUPMLCZ-IXCJQBJRSA-N
InChi Code
InChI=1S/C32H43Cl2N5O3/c1-2-26(37-14-3-4-15-37)22-42-29-8-7-13-35-30(29)23-11-18-38(19-12-23)31(40)28(36-32(41)39-16-5-6-17-39)20-24-9-10-25(33)21-27(24)34/h7-10,13,21,23,26,28H,2-6,11-12,14-20,22H2,1H3,(H,36,41)/t26-,28-/m1/s1
SMILES Code
O=C([C@H](NC(N1CCCC1)=O)CC2=CC=C(Cl)C=C2Cl)N3CCC(C4=NC=CC=C4OC[C@H](N5CCCC5)CC)CC3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SNT-207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
In vitro activity:
To be determined
In vivo activity:
SNT-207858 is a potential therapeutic treatment for cachexia patients. In this study, SNT-207707 and SNT-207858 were found to distinctly increase food intake in healthy mice. In a mouse model of adenocarcinoma, repeated oral administration of both compounds almost completely prevented tumor induced weight loss and diminished loss of lean body mass and fat mass. **Note: this article mistakenly labels “SNT207858” as “SNT209858” in the abstract. Reference: PLoS One. 2009;4(3):e4774. https://pubmed.ncbi.nlm.nih.gov/19295909/

Preparing Stock Solutions

The following data is based on the product molecular weight 616.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Weyermann P, Dallmann R, Magyar J, Anklin C, Hufschmid M, Dubach-Powell J, Courdier-Fruh I, Henneböhle M, Nordhoff S, Mondadori C. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. doi: 10.1371/journal.pone.0004774. Epub 2009 Mar 19. PMID: 19295909; PMCID: PMC2654097.
In vitro protocol:
To be determined
In vivo protocol:
1. Weyermann P, Dallmann R, Magyar J, Anklin C, Hufschmid M, Dubach-Powell J, Courdier-Fruh I, Henneböhle M, Nordhoff S, Mondadori C. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. doi: 10.1371/journal.pone.0004774. Epub 2009 Mar 19. PMID: 19295909; PMCID: PMC2654097.
1: Weyermann P, Dallmann R, Magyar J, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. doi:10.1371/journal.pone.0004774

View History

MG-262

MG-262