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MedKoo Cat#: 462412 | Name: SNT-207858
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist.

Chemical Structure

SNT-207858
SNT-207858
CAS#1104080-42-3

Theoretical Analysis

MedKoo Cat#: 462412

Name: SNT-207858

CAS#: 1104080-42-3

Chemical Formula: C32H45Cl4N5O3

Exact Mass: 0.0000

Molecular Weight: 689.54

Elemental Analysis: C, 55.74; H, 6.58; Cl, 20.56; N, 10.16; O, 6.96

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Related CAS #
1104662-66-9
Synonym
SNT-207858 HCl; SNT 207858 HCl; SNT207858 HCl; SNT-207858 hydrochloride; SNT 207858 hydrochloride; SNT207858 hydrochloride
IUPAC/Chemical Name
N-((R)-3-(2,4-dichlorophenyl)-1-oxo-1-(4-(3-((R)-2-(pyrrolidin-1-yl)butoxy)pyridin-2-yl)piperidin-1-yl)propan-2-yl)pyrrolidine-1-carboxamide dihydrochloride
InChi Key
DFRHMBGAOYBWHK-VXGCXGCYSA-N
InChi Code
InChI=1S/C32H43Cl2N5O3.2ClH/c1-2-26(37-14-3-4-15-37)22-42-29-8-7-13-35-30(29)23-11-18-38(19-12-23)31(40)28(36-32(41)39-16-5-6-17-39)20-24-9-10-25(33)21-27(24)34;;/h7-10,13,21,23,26,28H,2-6,11-12,14-20,22H2,1H3,(H,36,41);2*1H/t26-,28-;;/m1../s1
SMILES Code
[H]Cl.O=C(N1CCCC1)N[C@H](CC2=CC=C(Cl)C=C2Cl)C(N3CCC(C4=NC=CC=C4OC[C@H](N5CCCC5)CC)CC3)=O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Biological target: SNT-207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
In vitro activity:
To be determined
In vivo activity:
SNT-207858 is a potential therapeutic treatment for cachexia patients. In this study, SNT-207707 and SNT-207858 were found to distinctly increase food intake in healthy mice. In a mouse model of adenocarcinoma, repeated oral administration of both compounds almost completely prevented tumor induced weight loss and diminished loss of lean body mass and fat mass. **Note: this article mistakenly labels “SNT207858” as “SNT209858” in the abstract. Reference: PLoS One. 2009;4(3):e4774. https://pubmed.ncbi.nlm.nih.gov/19295909/

Preparing Stock Solutions

The following data is based on the product molecular weight 689.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Weyermann P, Dallmann R, Magyar J, Anklin C, Hufschmid M, Dubach-Powell J, Courdier-Fruh I, Henneböhle M, Nordhoff S, Mondadori C. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. doi: 10.1371/journal.pone.0004774. Epub 2009 Mar 19. PMID: 19295909; PMCID: PMC2654097.
In vitro protocol:
To be determined
In vivo protocol:
1. Weyermann P, Dallmann R, Magyar J, Anklin C, Hufschmid M, Dubach-Powell J, Courdier-Fruh I, Henneböhle M, Nordhoff S, Mondadori C. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. doi: 10.1371/journal.pone.0004774. Epub 2009 Mar 19. PMID: 19295909; PMCID: PMC2654097.
1: Weyermann P, Dallmann R, Magyar J, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. doi:10.1371/journal.pone.0004774