MedKoo Cat#: 561519 | Name: BKM1740

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BKM1740 is an inhibitor of survivin expression at both the mRNA and protein levels in vitro. BKM1740 induced apoptosis in prostate cancer (PCa) cells by repressing survivin.

Chemical Structure

BKM1740
BKM1740
CAS#1070966-97-0

Theoretical Analysis

MedKoo Cat#: 561519

Name: BKM1740

CAS#: 1070966-97-0

Chemical Formula: C39H46Cl2F5N3O9P2

Exact Mass: 927.2006

Molecular Weight: 928.64

Elemental Analysis: C, 50.44; H, 4.99; Cl, 7.63; F, 10.23; N, 4.52; O, 15.51; P, 6.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BKM1740; BKM-1740; BKM 1740;
IUPAC/Chemical Name
tetraethyl ((4-(3-(4-((2,6-dichlorobenzyl)oxy)phenyl)-2-(3-(perfluorophenyl)acrylamido)propanamido)piperidin-1-yl)methylene)(S,E)-bis(phosphonate)
InChi Key
MJDJHVSCDMJYOU-XCXBIEIDSA-N
InChi Code
InChI=1S/C39H46Cl2F5N3O9P2/c1-5-55-59(52,56-6-2)39(60(53,57-7-3)58-8-4)49-20-18-25(19-21-49)47-38(51)31(48-32(50)17-16-27-33(42)35(44)37(46)36(45)34(27)43)22-24-12-14-26(15-13-24)54-23-28-29(40)10-9-11-30(28)41/h9-17,25,31,39H,5-8,18-23H2,1-4H3,(H,47,51)(H,48,50)/b17-16+/t31-/m0/s1
SMILES Code
O=C([C@H](CC1=CC=C(OCC2=C(Cl)C=CC=C2Cl)C=C1)NC(/C=C/C3=C(F)C(F)=C(F)C(F)=C3F)=O)NC4CCN(C(P(OCC)(OCC)=O)P(OCC)(OCC)=O)CC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 928.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Seo SI, Gera L, Zhau HE, Qian WP, Iqbal S, Johnson NA, Zhang S, Zayzafoon M, Stewart J, Wang R, Chung LW, Wu D. BKM1740, an acyl-tyrosine bisphosphonate amide derivative, inhibits the bone metastatic growth of human prostate cancer cells by inducing apoptosis. Clin Cancer Res. 2008 Oct 1;14(19):6198-206. doi: 10.1158/1078-0432.CCR-08-1023. PubMed PMID: 18829499.