MedKoo Cat#: 584223 | Name: BK 129

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BK 129 is a local anesthetic which possesses relaxant properties. It appears to inhibit Ca2+ entry into the smooth muscle cell and Ca2+ release from sarcoplasmic reticulum.

Chemical Structure

BK 129
BK 129
CAS#105919-73-1

Theoretical Analysis

MedKoo Cat#: 584223

Name: BK 129

CAS#: 105919-73-1

Chemical Formula: C22H36N2O4

Exact Mass: 392.2675

Molecular Weight: 392.54

Elemental Analysis: C, 67.32; H, 9.24; N, 7.14; O, 16.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BK 129; BK-129; BK129
IUPAC/Chemical Name
Carbamic acid, (2-(pentyloxy)phenyl)-, 2-(hexahydro-1H-azepin-1-yl)-1-(methoxymethyl)ethyl ester
InChi Key
VVNITDZDOPJHAV-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H36N2O4/c1-3-4-11-16-27-21-13-8-7-12-20(21)23-22(25)28-19(18-26-2)17-24-14-9-5-6-10-15-24/h7-8,12-13,19H,3-6,9-11,14-18H2,1-2H3,(H,23,25)
SMILES Code
O=C(OC(COC)CN1CCCCCC1)NC2=CC=CC=C2OCCCCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 392.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sotníková R. Effect of a new antiarrhythmic BK 129 on canine vascular smooth muscle in vitro. Methods Find Exp Clin Pharmacol. 1992 Apr;14(3):175-81. PubMed PMID: 1625501. 2: Gibala P, Sotníková R, Knezl V, Drímal J. Antiarrhythmic activity of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid. Arzneimittelforschung. 1987 Feb;37(2):149-52. PubMed PMID: 3580018. 3: Gibala P, Sotníková R, Knezl V, Drímal J. Cardiac electrophysiologic actions of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid in the anesthetized dog. Arzneimittelforschung. 1987 Mar;37(3):326-8. PubMed PMID: 3593445. 4: Stolc S. Inhibition of ion currents in membrane of sensory neuron by the antiarrhythmic drug BK 129 and selected Ca2+ entry blockers. Gen Physiol Biophys. 1993 Dec;12(6):517-31. Erratum in: Gen Physiol Biophys 1994 Aug;13(4):339. PubMed PMID: 8070644. 5: Bednáriková A, Lehotay J, Cizmárik J. Study of local anesthetics. Part 123: HPLC study of pentacaine, heptacaine and carbisocaine. Pharmazie. 1994 Aug;49(8):577-9. PubMed PMID: 7938146.