Synonym
EXP921; X9121; Sibopirdine;
IUPAC/Chemical Name
5,5-bis(4-pyridinylmethyl)-5H-cyclopenta(2,1-b-3,4-b')dipyridine
InChi Key
FJYRSJDIZKTXKB-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H18N4/c1-3-19-21(26-9-1)22-20(4-2-10-27-22)23(19,15-17-5-11-24-12-6-17)16-18-7-13-25-14-8-18/h1-14H,15-16H2
SMILES Code
C12=NC=CC=C1C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CN=C52
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
350.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wong YN, Quon CY, Holm KA, Burcham DL, Frey NL, Huang SM, Lam GN. Pharmacokinetics and metabolism of EXP921, a novel cognitive enhancer, in rats. Drug Metab Dispos. 1996 Feb;24(2):172-9. PubMed PMID: 8742228.
2: Nugiel DA, Voss ME, Brittelli DR, Calabrese JC. An approach to the design of novel cognitive enhancers using molecular modeling and X-ray crystallography. Drug Des Discov. 1995 Apr;12(4):289-95. PubMed PMID: 9040989.
3: Kapil RP, Lee W Jr, Padovani PK, Wong NY, Holm KA, Lam GN. Determination of a novel cognitive enhancer, X9121, and its mono N-oxide metabolite, XG696, in dog plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Appl. 1995 Mar 10;665(1):226-31. PubMed PMID: 7795797.
