Synonym
GSK-690; GSK 690; GSK690; GSK-354; GSK 354;
IUPAC/Chemical Name
(R)-4-[5-(Pyrrolidin-3-ylmethoxy)-2-p-tolyl-pyridin-3-yl]-benzonitrile
InChi Key
IQVDLEXWAPYWDT-LJQANCHMSA-N
InChi Code
InChI=1S/C24H23N3O/c1-17-2-6-21(7-3-17)24-23(20-8-4-18(13-25)5-9-20)12-22(15-27-24)28-16-19-10-11-26-14-19/h2-9,12,15,19,26H,10-11,14,16H2,1H3/t19-/m1/s1
SMILES Code
N#CC1=CC=C(C2=CC(OC[C@H]3CNCC3)=CN=C2C4=CC=C(C)C=C4)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Inhibition of lysine specific demethylase 1 (LSD1) has been shown to induce the differentiation of leukemia stem cells in acute myeloid leukemia (AML).
Preparing Stock Solutions
The following data is based on the
product
molecular weight
369.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mould DP, Bremberg U, Jordan AM, Geitmann M, McGonagle AE, Somervaille TCP,
Spencer GJ, Ogilvie DJ. Development and evaluation of
4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific
demethylase 1. Bioorg Med Chem Lett. 2017 Aug 24. pii: S0960-894X(17)30853-3.
doi: 10.1016/j.bmcl.2017.08.052. [Epub ahead of print] PubMed PMID: 28927796.
2: Mould DP, Alli C, Bremberg U, Cartic S, Jordan AM, Geitmann M, Maiques-Diaz A,
McGonagle AE, Somervaille TCP, Spencer GJ, Turlais F, Ogilvie D. Development of
(4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific
Demethylase 1. J Med Chem. 2017 Sep 21. doi: 10.1021/acs.jmedchem.7b00462. [Epub
ahead of print] PubMed PMID: 28892629.
