Synonym
Brovanexine; U 389; U389; U-389
IUPAC/Chemical Name
[4-[[2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]phenyl]carbamoyl]-2-methoxyphenyl] acetate
InChi Key
DQTRREPKGJIABH-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H28Br2N2O4/c1-15(29)32-21-10-9-16(12-22(21)31-3)24(30)27-23-17(11-18(25)13-20(23)26)14-28(2)19-7-5-4-6-8-19/h9-13,19H,4-8,14H2,1-3H3,(H,27,30)
SMILES Code
CC(OC1=CC=C(C(NC2=C(CN(C3CCCCC3)C)C=C(Br)C=C2Br)=O)C=C1OC)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
568.31
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Garcia-Rafanell J, Lleonart F. [Physicochemical characteristics of the tracheobronchial mucous secretion of lambs. Modification by a new mucolytic agent (Brovanexine UR-389)]. Therapie. 1976 Jul-Aug;31(4):483-90. French. PubMed PMID: 12589.
2: Takeda H, Shimoyama K, Misawa M, Yanaura S, Yamazaki M, Kubo S. [Changes in secretory activity of tracheal submucosal glands by repeated treatment with brovanexine and BR-227 in rats]. Nihon Yakurigaku Zasshi. 1984 Aug;84(2):251-7. Japanese. PubMed PMID: 6489870.
3: Yamazaki M, Shimo T, Tanaka K, Kubo S, Ito Y, Yanaura S, Takeda H. [Sequential changes of the activities of the dog tracheal secretory cells caused by intraduodenal application of brovanexine]. Nihon Yakurigaku Zasshi. 1983 Jul;82(1):57-66. Japanese. PubMed PMID: 6618349.
4: Kasé Y, Hidaka T, Miyata T, Takahama K, Okano Y, Kubo S, Yamazaki M. [Pharmacological effects of brovanexine hydrochloride (BR-222) on the respiratory tract system, particularly on the respiratory tract fluid, mucociliary transport and cough]. Nihon Yakurigaku Zasshi. 1984 Feb;83(2):173-81. Japanese. PubMed PMID: 6745807.
5: Takeda H, Kasamatsu S, Misawa M, Yanaura S. [Effect of brovanexine on secretory activities of tracheal secretory cells]. Nihon Yakurigaku Zasshi. 1983 Jan;81(1):29-37. Japanese. PubMed PMID: 6852680.
6: García-Rafanell J, Bellés L, Morell J. [Increase of rabbit tracheo-nasal mucus secretion by a new mucolytic agent: brovanexine (UR-389) (author's transl)]. Arch Farmacol Toxicol. 1976 Apr;2(1):61-8. Spanish. PubMed PMID: 1275572.
7: Rimbau V, Torralba A. [Pharmacokinetic and distribution studies in rats and mice of 14C-brovanexine (author's transl)]. Arch Farmacol Toxicol. 1978 Aug;4(2):253-60. Spanish. PubMed PMID: 727838.
8: Unakami S, Komoda T, Watanabe M, Tanimoto Y, Sakagishi Y, Ikezawa H. Molecular nature of three liver alkaline phosphatases detected by drug administration in vivo: differences between soluble and membranous enzymes. Comp Biochem Physiol B. 1987;88(1):111-8. PubMed PMID: 2824118.
