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MedKoo Cat#: 561407 | Name: Spiclomazine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Spiclomazine HCl induces apoptosis associated with the suppression of cell viability, migration and invasion in pancreatic carcinoma cells. Spiclomazine HCl treatment causes a reduction in viability in pancreatic carcinoma cell lines CFPAC-1 and MIA PaCa-2 in vitro.

Chemical Structure

Spiclomazine HCl
Spiclomazine HCl
CAS#27007-85-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 561407

Name: Spiclomazine HCl

CAS#: 27007-85-8 (HCl)

Chemical Formula: C22H25Cl2N3OS2

Exact Mass:

Molecular Weight: 482.48

Elemental Analysis: C, 54.77; H, 5.22; Cl, 14.69; N, 8.71; O, 3.32; S, 13.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
24527-27-3 (free base) 27007-85-8 (HCl)
Synonym
Spiclomazine HCl; Spiclomazine Hydrochloride; APY606; APY-606; Diceplon; Disepron; Clospirazine hydrochloride;
IUPAC/Chemical Name
8-[3-(2-Chlorophenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one hydrochloride
InChi Key
JRSBQVOEILNXGS-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H24ClN3OS2.ClH/c23-16-6-7-20-18(14-16)26(17-4-1-2-5-19(17)29-20)11-3-10-25-12-8-22(9-13-25)24-21(27)15-28-22;/h1-2,4-7,14H,3,8-13,15H2,(H,24,27);1H
SMILES Code
O=C1CSC2(CCN(CCCN3C4=C(C=CC=C4)SC5=CC=C(Cl)C=C35)CC2)N1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 482.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhao W, Li D, Liu Z, Zheng X, Wang J, Wang E. Spiclomazine induces apoptosis associated with the suppression of cell viability, migration and invasion in pancreatic carcinoma cells. PLoS One. 2013 Jun 20;8(6):e66362. doi: 10.1371/journal.pone.0066362. Print 2013. PubMed PMID: 23840452; PubMed Central PMCID: PMC3688794. 2: Kuribara H, Tadokoro S. Correlation between antiavoidance activities of antipsychotic drugs in rats and daily clinical doses. Pharmacol Biochem Behav. 1981 Feb;14(2):181-92. PubMed PMID: 6111088.