Spiclomazine (free base) | CAS# 24527-27-3 (free base) | antipsychotic

MedKoo Cat#: 413184 | Name: Spiclomazine (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Spiclomazine (free base) is an antipsychotic drug.

Chemical Structure

Spiclomazine (free base)

CAS#24527-27-3 (free base)

Theoretical Analysis

MedKoo Cat#: 413184

Name: Spiclomazine (free base)

CAS#: 24527-27-3 (free base)

Chemical Formula: C22H24ClN3OS2

Exact Mass: 445.1049

Molecular Weight: 446.02

Elemental Analysis: C, 59.24; H, 5.42; Cl, 7.95; N, 9.42; O, 3.59; S, 14.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

24527-27-3 (free base) 27007-85-8 (HCl)

Synonym

Spiclomazine (free base); Spiclomazine; Spiclomazinum; Clospirazine hydrochloride

IUPAC/Chemical Name

8-(3-(2-Chloro-10-phenothiazinyl)propyl)-1-thia-4,8-diazaspiro(4,5)decan-3-one

InChi Key

CFOYBMUYCBSDAL-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H24ClN3OS2/c23-16-6-7-20-18(14-16)26(17-4-1-2-5-19(17)29-20)11-3-10-25-12-8-22(9-13-25)24-21(27)15-28-22/h1-2,4-7,14H,3,8-13,15H2,(H,24,27)

SMILES Code

O=C1CSC2(CCN(CCCN3C4=C(C=CC=C4)SC5=CC=C(Cl)C=C35)CC2)N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 446.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Guo X, Zhao W, Liu Z, Wang J. Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer. Oncotarget. 2018 Jan 8;9(6):6938-6951. doi: 10.18632/oncotarget.24025. PMID: 29467941; PMCID: PMC5805527. 2: Zhao W, Li D, Liu Z, Zheng X, Wang J, Wang E. Spiclomazine induces apoptosis associated with the suppression of cell viability, migration and invasion in pancreatic carcinoma cells. PLoS One. 2013 Jun 20;8(6):e66362. doi: 10.1371/journal.pone.0066362. PMID: 23840452; PMCID: PMC3688794. 3: Kuribara H, Tadokoro S. Correlation between antiavoidance activities of antipsychotic drugs in rats and daily clinical doses. Pharmacol Biochem Behav. 1981 Feb;14(2):181-92. doi: 10.1016/0091-3057(81)90241-0. PMID: 6111088.