Pterostilbene | CAS#537-42-8 | antioxidant

MedKoo Cat#: 561381 | Name: Pterostilbene

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pterostilbene is an antioxidant that primarily exists in blueberries, grapevines and heartwood of red sandalwood. Pterostilbene also has chemopreventive, antiinflammatory, antidiabetic, antidyslipidemic, antiatherosclerotic and neuroprotective effects.

Chemical Structure

Pterostilbene

CAS#537-42-8

Theoretical Analysis

MedKoo Cat#: 561381

Name: Pterostilbene

CAS#: 537-42-8

Chemical Formula: C16H16O3

Exact Mass: 256.1099

Molecular Weight: 256.30

Elemental Analysis: C, 74.98; H, 6.29; O, 18.73

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 350.00
1g	USD 500.00

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Related CAS #

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Synonym

Pterostilbene; PS;

IUPAC/Chemical Name

4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol

InChi Key

VLEUZFDZJKSGMX-ONEGZZNKSA-N

InChi Code

InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+

SMILES Code

OC1=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C=C1

Appearance

White to off-white, solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Certificate of Analysis

View CoA: current batch, Lot# T7C12I04

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 256.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cui C, Zheng J, Zhang H, Xing Z. Pterostilbene ameliorates oxidative stress and neuronal apoptosis after intracerebral hemorrhage via the sirtuin 1-mediated Nrf2 pathway in vivo and in vitro. J Stroke Cerebrovasc Dis. 2024 Aug 20;33(11):107950. doi: 10.1016/j.jstrokecerebrovasdis.2024.107950. Epub ahead of print. PMID: 39173685. 2: Li M, Li H. Research progress on inhibitors and inhibitory mechanisms of mycotoxin biosynthesis. Mycotoxin Res. 2024 Aug 21. doi: 10.1007/s12550-024-00553-2. Epub ahead of print. PMID: 39164466. 3: Sharma AN, Upadhyay PK, Dewangan HK. Dual combination of resveratrol and pterostilbene aqueous core nanocapsules for integrated prostate cancer targeting. Ther Deliv. 2024 Aug 12:1-14. doi: 10.1080/20415990.2024.2380239. Epub ahead of print. PMID: 39129676. 4: Ruan B, Zhang X, Li B, Liu X, Chen L, Xia C. Design, Synthesis, in Vitro and in Vivo Biological Evaluation of Pterostilbene Derivatives for the Treatment of Inflammatory Bowel Disease. Chem Biodivers. 2024 Aug 9:e202401081. doi: 10.1002/cbdv.202401081. Epub ahead of print. PMID: 39126188. 5: Foda AM, Ibrahim SS, Ibrahim SM, Elbaz EM. Pterostilbene Ameliorates Cognitive Impairment in Polycystic Ovary Syndrome Rat Model through Improving Insulin Resistance via the IRS-1/PI3K/Akt/GSK-3β Pathway: A Comparative Study with Metformin. ACS Chem Neurosci. 2024 Aug 21;15(16):3064-3077. doi: 10.1021/acschemneuro.4c00352. Epub 2024 Aug 9. PMID: 39119909. 6: Lv K, Song J, Wang J, Zhao W, Yang F, Feiya J, Bai L, Guan W, Liu J, Ho CT, Li S, Zhao H, Wang Z. Pterostilbene Alleviates Dextran Sodium Sulfate (DSS)-Induced Intestinal Barrier Dysfunction Involving Suppression of a S100A8-TLR-4-NF-κB Signaling Cascade. J Agric Food Chem. 2024 Aug 21;72(33):18489-18496. doi: 10.1021/acs.jafc.4c03258. Epub 2024 Aug 6. PMID: 39106077. 7: Carrera-Juliá S, Obrador E, López-Blanch R, Oriol-Caballo M, Moreno-Murciano P, Estrela JM. Ketogenic effect of coconut oil in ALS patients. Front Nutr. 2024 Jul 17;11:1429498. doi: 10.3389/fnut.2024.1429498. PMID: 39086545; PMCID: PMC11289842. 8: Zatloukalova M, Hanyk J, Papouskova B, Kabelac M, Vostalova J, Vacek J. Tapinarof and its structure-activity relationship for redox chemistry and phototoxicity on human skin keratinocytes. Free Radic Biol Med. 2024 Jul 26;223:212-223. doi: 10.1016/j.freeradbiomed.2024.07.032. Epub ahead of print. PMID: 39067626. 9: He H, Li T. Pterostilbene exerts anti-lung squamous cell carcinoma function by suppressing the level of KANK3. Chem Biol Drug Des. 2024 Jul;104(1):e14597. doi: 10.1111/cbdd.14597. PMID: 39044124. 10: Zhang H, Liu Y, Zhang L, Tian Z, Zhang H, Jiang H. Rapid identification of chemical components and screening of acetylcholinesterase inhibitors from Dalbergia odorifera based on mass defect and diagnostic ion filtering strategy, affinity ultrafiltration, and liquid chromatography-tandem mass spectrometry. J Sep Sci. 2024 Jul;47(14):e2400288. doi: 10.1002/jssc.202400288. PMID: 39034832. 11: Harithpriya K, Ganesan K, Ramkumar KM. Pterostilbene Reverses Epigenetic Silencing of Nrf2 and Enhances Antioxidant Response in Endothelial Cells in Hyperglycemic Microenvironment. Nutrients. 2024 Jun 27;16(13):2045. doi: 10.3390/nu16132045. PMID: 38999793; PMCID: PMC11242982. 12: Yin Z, Sun X, Chai X, Zhou X, Wang Y, Liu M, Feng X. The Effects of Dietary Pterostilbene on the Immune Response, Antioxidant Function, and Jejunal Structure of Broilers. Animals (Basel). 2024 Jun 22;14(13):1851. doi: 10.3390/ani14131851. PMID: 38997964; PMCID: PMC11240711. 13: Fan Y, He X, Chen M, Guo S, Dong Z. Pterostilbene alleviates MPTP-induced neurotoxicity by targeting neuroinflammation and oxidative stress. Biochem Biophys Res Commun. 2024 Oct 15;729:150358. doi: 10.1016/j.bbrc.2024.150358. Epub 2024 Jul 5. PMID: 38981401. 14: Mahmutović-Dizdarević I, Mesic A, Jerković-Mujkić A, Žujo B, Avdić M, Hukić M, Omeragić E, Osmanović A, Špirtović-Halilović S, Ahmetovski S, Mujkanović S, Pramenković E, Salihović M. Biological potential, chemical profiling, and molecular docking study of Morus alba L. extracts. Fitoterapia. 2024 Sep;177:106114. doi: 10.1016/j.fitote.2024.106114. Epub 2024 Jul 5. PMID: 38971331. 15: Sepehri S, Khedmati M, Yousef-Nejad F, Mahdavi M. Medicinal chemistry perspective on the structure-activity relationship of stilbene derivatives. RSC Adv. 2024 Jun 20;14(28):19823-19879. doi: 10.1039/d4ra02867h. PMID: 38903666; PMCID: PMC11188052. 16: Koh YC, Yao CH, Lee PS, Nagabhushanam K, Ho CT, Pan MH. Hepatoprotective effect of dietary pterostilbene against high-fat-diet-induced lipid accumulation exacerbated by chronic jet lag via SIRT1 and SIRT3 activation. Phytother Res. 2024 Aug;38(8):4099-4113. doi: 10.1002/ptr.8262. Epub 2024 Jun 20. PMID: 38899498. 17: Samuel Rajan IAP, Rajendran S. DABCO-catalyzed esterification of N-pivaloyl-activated amides. Org Biomol Chem. 2024 Jun 26;22(25):5170-5180. doi: 10.1039/d4ob00752b. PMID: 38864233. 18: Golubnitschaja O, Kapinova A, Sargheini N, Bojkova B, Kapalla M, Heinrich L, Gkika E, Kubatka P. Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care-clinically relevant 3PM innovation. EPMA J. 2024 Apr 18;15(2):163-205. doi: 10.1007/s13167-024-00358-4. PMID: 38841620; PMCID: PMC11148002. 19: Wang L, Zhao Z, Li X, Zhao X, Li S, Li H. Ecofriendly dual-function cotton fabric with antibacterial and anti-adhesion properties based on modified natural materials. Int J Biol Macromol. 2024 Jun;271(Pt 1):132698. doi: 10.1016/j.ijbiomac.2024.132698. Epub 2024 May 31. PMID: 38824104. 20: Yin S, Hou J, Li J, Zeng C, Chen S, Zhang H, Tian X. Polydopamine-modified black phosphorus nanosheet drug delivery system for the treatment of ischemic stroke. Regen Biomater. 2024 May 2;11:rbae046. doi: 10.1093/rb/rbae046. PMID: 38769994; PMCID: PMC11105953.