Ranosidenib, also known as HMPL-306, is an isocitrate dehydrogenase (IDH) inhibitor. IDH inhibitors are compounds that target mutations in the IDH enzyme, which are implicated in various cancers, including acute myeloid leukemia (AML). By inhibiting mutant IDH enzymes, these inhibitors can reduce the production of the oncometabolite 2-hydroxyglutarate (2-HG), thereby promoting the differentiation of malignant cells and inhibiting tumor growth.
MedKoo Cat#: 127805
Name: Ranosidenib
CAS#: 2301974-60-5
Chemical Formula: C15H16F9N5O
Exact Mass: 453.1211
Molecular Weight: 453.31
Elemental Analysis: C, 39.74; H, 3.56; F, 37.72; N, 15.45; O, 3.53
The following data is based on the product molecular weight 453.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
