MedKoo Cat#: 561346 | Name: JX-401

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JX-401 is a p38alpha inhibitor containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation.

Chemical Structure

JX-401
JX-401
CAS#349087-34-9

Theoretical Analysis

MedKoo Cat#: 561346

Name: JX-401

CAS#: 349087-34-9

Chemical Formula: C21H25NO2S

Exact Mass: 355.1606

Molecular Weight: 355.50

Elemental Analysis: C, 70.95; H, 7.09; N, 3.94; O, 9.00; S, 9.02

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Synonym
JX-401; JX 401; JX401;
IUPAC/Chemical Name
1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine
InChi Key
OMGLGPKQUFSRNN-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3
SMILES Code
O=C(N1CCC(CC2=CC=CC=C2)CC1)C3=CC=C(SC)C=C3OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 355.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Friedmann Y, Shriki A, Bennett ER, Golos S, Diskin R, Marbach I, Bengal E, Engelberg D. JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol Pharmacol. 2006 Oct;70(4):1395-405. Epub 2006 Jul 17. PubMed PMID: 16847144.