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MedKoo Cat#: 561268 | Name: LUF7346
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LUF7346 is an allosteric modulator of hERG. LUF7346 rescued genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells.

Chemical Structure

LUF7346
LUF7346
CAS#1821638-40-7

Theoretical Analysis

MedKoo Cat#: 561268

Name: LUF7346

CAS#: 1821638-40-7

Chemical Formula: C20H15BrN2O3

Exact Mass: 410.0266

Molecular Weight: 411.26

Elemental Analysis: C, 58.41; H, 3.68; Br, 19.43; N, 6.81; O, 11.67

Price and Availability

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5mg USD 365.00 2 weeks
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Related CAS #
No Data
Synonym
LUF7346; LUF 7346; LUF-7346
IUPAC/Chemical Name
2-[4-(2-Bromo-benzoyl)-phenoxy]-N-pyridin-3-yl-acetamide
InChi Key
QNWXOXKHLFTJBA-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H15BrN2O3/c21-18-6-2-1-5-17(18)20(25)14-7-9-16(10-8-14)26-13-19(24)23-15-4-3-11-22-12-15/h1-12H,13H2,(H,23,24)
SMILES Code
O=C(NC1=CC=CN=C1)COC2=CC=C(C(C3=CC=CC=C3Br)=O)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
LUF7346 is an allosteric modulator of hERG.
In vitro activity:
By slowing IK r deactivation and positively shifting IK r inactivation, the small molecule LUF7346 effectively rescued all of these conditions, demonstrating in a human system that allosteric modulation of hERG may be useful as an approach to treat inherited and drug-induced LQTS. Reference: EMBO Mol Med. 2016 Sep 1;8(9):1065-81. https://pubmed.ncbi.nlm.nih.gov/27470144/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 411.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Sala L, Yu Z, Ward-van Oostwaard D, van Veldhoven JP, Moretti A, Laugwitz KL, Mummery CL, IJzerman AP, Bellin M. A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells. EMBO Mol Med. 2016 Sep 1;8(9):1065-81. doi: 10.15252/emmm.201606260. PMID: 27470144; PMCID: PMC5009811.
In vitro protocol:
1. Sala L, Yu Z, Ward-van Oostwaard D, van Veldhoven JP, Moretti A, Laugwitz KL, Mummery CL, IJzerman AP, Bellin M. A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells. EMBO Mol Med. 2016 Sep 1;8(9):1065-81. doi: 10.15252/emmm.201606260. PMID: 27470144; PMCID: PMC5009811.
In vivo protocol:
TBD
1: Sala L, Yu Z, Ward-van Oostwaard D, van Veldhoven JP, Moretti A, Laugwitz KL, Mummery CL, IJzerman AP, Bellin M. A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells. EMBO Mol Med. 2016 Sep 1;8(9):1065-81. doi: 10.15252/emmm.201606260. Print 2016 Sep. PubMed PMID:27470144; PubMed Central PMCID: PMC5009811.