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MedKoo Cat#: 561050 | Name: ISAM-140
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ISAM-140 is a potent and highly selective A2B adenosine receptor antagonist.

Chemical Structure

ISAM-140
ISAM-140
CAS#932191-62-3

Theoretical Analysis

MedKoo Cat#: 561050

Name: ISAM-140

CAS#: 932191-62-3

Chemical Formula: C19H19N3O3

Exact Mass: 337.1426

Molecular Weight: 337.38

Elemental Analysis: C, 67.64; H, 5.68; N, 12.46; O, 14.23

Price and Availability

Size Price Availability Quantity
5mg USD 300.00 2 Weeks
25mg USD 800.00 2 Weeks
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Related CAS #
No Data
Synonym
ISAM-140; ISAM 140; ISAM140
IUPAC/Chemical Name
4-(2-Furanyl)-4,10-dihydro-2-methylpyrimido[1,2-a]benzimidazole-3-carboxylic acid-1-methylethyl ester
InChi Key
NYHLRBMDXQBOIB-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H19N3O3/c1-11(2)25-18(23)16-12(3)20-19-21-13-7-4-5-8-14(13)22(19)17(16)15-9-6-10-24-15/h4-11,17H,1-3H3,(H,20,21)
SMILES Code
O=C(C1=C(C)N=C2NC3=CC=CC=C3N2C1C4=CC=CO4)OC(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
ISAM-140 (22b) is a potent and highly selective A2B adenosine receptor antagonist with a Ki of 3.49 nM.
In vitro activity:
Subsequently affinity evaluation for both A2A and A2B receptors demonstrate the stereospecific and selective recognition of (S)-ISAM140 to the A2BAR. Reference: Sci Rep. 2021 Jul 8;11(1):14171. https://pubmed.ncbi.nlm.nih.gov/34238993/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 337.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Wang X, Jespers W, Prieto-Díaz R, Majellaro M, IJzerman AP, van Westen GJP, Sotelo E, Heitman LH, Gutiérrez-de-Terán H. Identification of V6.51L as a selectivity hotspot in stereoselective A2B adenosine receptor antagonist recognition. Sci Rep. 2021 Jul 8;11(1):14171. doi: 10.1038/s41598-021-93419-x. PMID: 34238993; PMCID: PMC8266863.
In vitro protocol:
1. Wang X, Jespers W, Prieto-Díaz R, Majellaro M, IJzerman AP, van Westen GJP, Sotelo E, Heitman LH, Gutiérrez-de-Terán H. Identification of V6.51L as a selectivity hotspot in stereoselective A2B adenosine receptor antagonist recognition. Sci Rep. 2021 Jul 8;11(1):14171. doi: 10.1038/s41598-021-93419-x. PMID: 34238993; PMCID: PMC8266863.
In vivo protocol:
TBD
1: El Maatougui A, Azuaje J, González-Gómez M, Miguez G, Crespo A, Carbajales C, Escalante L, García-Mera X, Gutiérrez-de-Terán H, Sotelo E. Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes. J Med Chem. 2016 Mar 10;59(5):1967-83. doi: 10.1021/acs.jmedchem.5b01586. Epub 2016 Feb 9. PubMed PMID: 26824742.