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MedKoo Cat#: 540106 | Name: Diclazuril
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diclazuril is a coccidiostat and GAPDH inhibitor used to prevent parasitic contamination of livestock and poultry feed.

Chemical Structure

Diclazuril
CAS#101831-37-2 (free base)

Theoretical Analysis

MedKoo Cat#: 540106

Name: Diclazuril

CAS#: 101831-37-2 (free base)

Chemical Formula: C17H9Cl3N4O2

Exact Mass: 405.9791

Molecular Weight: 407.63

Elemental Analysis: C, 50.09; H, 2.23; Cl, 26.09; N, 13.74; O, 7.85

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 weeks
5g USD 450.00 2 weeks
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Related CAS #
112209-98-0 (potassium) 101831-37-2 (free base) 112209-99-1 (sodium)
Synonym
Clinacox; DCL; Diclazuril; DRG-0079; DRG0079; DRG-0079; R-64433; R 64433; R64433; P-64433; P 64433; P64433; Vecoxan; Nuoqiu;
IUPAC/Chemical Name
2-(4-chlorophenyl)-2-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenyl)acetonitrile
InChi Key
ZSZFUDFOPOMEET-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H9Cl3N4O2/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24/h1-6,8,12H,(H,23,25,26)
SMILES Code
N#CC(C1=CC=C(Cl)C=C1)C2=C(Cl)C=C(N(C(N3)=O)N=CC3=O)C=C2Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 407.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Oz HS, Tobin T. Diclazuril Protects against Maternal Gastrointestinal Syndrome and Congenital Toxoplasmosis. Int J Clin Med. 2014 Jan 1;5(3):93-101. PubMed PMID: 24851194; PubMed Central PMCID: PMC4025969. 2: Philippe P, Alzieu JP, Taylor MA, Dorchies P. Comparative efficacy of diclazuril (Vecoxan®) and toltrazuril (Baycox bovis®) against natural infections of Eimeria bovis and Eimeria zuernii in French calves. Vet Parasitol. 2014 Dec 15;206(3-4):129-37. PubMed PMID: 25458561. 3: Pusterla N, Packham A, Mackie S, Kass PH, Hunyadi L, Conrad PA. Daily feeding of diclazuril top dress pellets in foals reduces seroconversion to Sarcocystis neurona. Vet J. 2015 Nov;206(2):236-8. doi: 10.1016/j.tvjl.2015.07.018. Epub 2015 Jul 23. PubMed PMID: 26346260. 4: Zhou BH, Liu LL, Liu J, Yuan FW, Tian EJ, Wang HW. Effect of Diclazuril on the Bursa of Fabricius Morphology and SIgA Expression in Chickens Infected with Eimeria tenella. Korean J Parasitol. 2015 Dec;53(6):675-82. doi: 10.3347/kjp.2015.53.6.675. Epub 2015 Dec 31. PubMed PMID: 26797433; PubMed Central PMCID: PMC4725230. 5: Shen XJ, Li T, Fu JJ, Zhang KY, Wang XY, Liu YC, Zhang HJ, Fan C, Fei CZ, Xue FQ. Proteomic analysis of the effect of diclazuril on second-generation merozoites of Eimeria tenella. Parasitol Res. 2014 Mar;113(3):903-9. doi: 10.1007/s00436-013-3721-8. Epub 2013 Dec 18. PubMed PMID: 24346578. 6: Tian EJ, Zhou BH, Wang XY, Zhao J, Deng W, Wang HW. Effect of diclazuril on intestinal morphology and SIgA expression in chicken infected with Eimeria tenella. Parasitol Res. 2014 Nov;113(11):4057-64. doi: 10.1007/s00436-014-4074-7. Epub 2014 Aug 26. PubMed PMID: 25154426. 7: Oz HS. Novel Synergistic Protective Efficacy of Atovaquone and Diclazuril on Fetal-Maternal Toxoplasmosis. Int J Clin Med. 2014 Aug;5(15):921-932. PubMed PMID: 25210646; PubMed Central PMCID: PMC4157831. 8: Hunyadi L, Papich MG, Pusterla N. Pharmacokinetics of a low dose and FDA-labeled dose of diclazuril administered orally as a pelleted topdressing in adult horses. J Vet Pharmacol Ther. 2015 Jun;38(3):243-8. doi: 10.1111/jvp.12176. Epub 2014 Oct 20. Erratum in: J Vet Pharmacol Ther. 2015 Dec;38(6):623-4. PubMed PMID: 25329774. 9: Zechner G, Bauer C, Jacobs J, Goossens L, Vertenten G, Taylor MA. Efficacy of diclazuril and toltrazuril in the prevention of coccidiosis in dairy calves under field conditions. Vet Rec. 2015 Jan 31;176(5):126. doi: 10.1136/vr.102237. Epub 2014 Nov 4. PubMed PMID: 25371497. 10: Oz HS. Toxoplasmosis complications and novel therapeutic synergism combination of diclazuril plus atovaquone. Front Microbiol. 2014 Sep 15;5:484. doi: 10.3389/fmicb.2014.00484. eCollection 2014. PubMed PMID: 25309522; PubMed Central PMCID: PMC4164033. 11: Rezk MR. Selective determination of diclazuril in the presence of its degradation products. J Chromatogr Sci. 2015 Feb;53(2):302-6. doi: 10.1093/chromsci/bmu059. Epub 2014 Jul 6. PubMed PMID: 25002681. 12: Zhou BH, Wang HW, Zhao ZS, Liu M, Yan WC, Zhao J, Zhang Z, Xue FQ. A novel serine/threonine protein phosphatase type 5 from second-generation merozoite of Eimeria tenella is associated with diclazuril-induced apoptosis. Parasitol Res. 2013 Apr;112(4):1771-80. doi: 10.1007/s00436-013-3336-0. Epub 2013 Feb 17. PubMed PMID: 23417098. 13: Bosco A, Rinaldi L, Cappelli G, Saratsis A, Nisoli L, Cringoli G. Metaphylactic treatment strategies with toltrazuril and diclazuril and growth performance of buffalo calves exposed to a natural eimeria infection. Vet Parasitol. 2015 Sep 15;212(3-4):408-10. doi: 10.1016/j.vetpar.2015.06.034. Epub 2015 Jul 13. PubMed PMID: 26215929. 14: Shen X, Wang C, Zhu Q, Li T, Yu L, Zheng W, Fei C, Qiu M, Xue F. Effect of the diclazuril on Hsp90 in the second-generation merozoites of Eimeria tenella. Vet Parasitol. 2012 Apr 30;185(2-4):290-5. doi: 10.1016/j.vetpar.2011.10.018. Epub 2011 Oct 20. PubMed PMID: 22075039. 15: Wang C, Han C, Li T, Yang D, Shen X, Fan Y, Xu Y, Zheng W, Fei C, Zhang L, Xue F. Nuclear translocation and accumulation of glyceraldehyde-3-phosphate dehydrogenase involved in diclazuril-induced apoptosis in Eimeria tenella (E. tenella). Vet Res. 2013 May 7;44:29. doi: 10.1186/1297-9716-44-29. PubMed PMID: 23651214; PubMed Central PMCID: PMC3655105. 16: Taylor MA, Marshall RN, Marshall JA, Catchpole J, Bartram D. Dose-response effects of diclazuril against pathogenic species of ovine coccidia and the development of protective immunity. Vet Parasitol. 2011 May 31;178(1-2):48-57. doi: 10.1016/j.vetpar.2010.12.024. Epub 2010 Dec 25. PubMed PMID: 21232870. 17: Bilandžić N, Dolenc J, Gačnik KŠ, Varenina I, Kolanović BS. Feed additives diclazuril and nicarbazin in egg and liver samples from Croatian farms. Food Addit Contam Part B Surveill. 2013;6(2):90-7. doi: 10.1080/19393210.2012.727474. Epub 2012 Oct 5. PubMed PMID: 24779872. 18: Romero J, Sanabria R, Travería G, Di Paolo L, Peralta L. Metaphylactic effect of Diclazuril 0.25% in suckling beef calves, during a coccidiosis outbreak in extensive farming. Vet Parasitol. 2013 Mar 31;193(1-3):277-80. doi: 10.1016/j.vetpar.2012.11.022. Epub 2012 Nov 27. PubMed PMID: 23276597. 19: Ruiz A, Guedes AC, Muñoz MC, Molina JM, Hermosilla C, Martín S, Hernández YI, Hernández A, Pérez D, Matos L, López AM, Taubert A. Control strategies using diclazuril against coccidiosis in goat kids. Parasitol Res. 2012 Jun;110(6):2131-6. doi: 10.1007/s00436-011-2746-0. Epub 2011 Dec 23. PubMed PMID: 22193521. 20: Lindsay DS, Rippey NS, Toivio-Kinnucan MA, Blagburn BL. Ultrastructural effects of diclazuril against Toxoplasma gondii and investigation of a diclazuril-resistant mutant. J Parasitol. 1995 Jun;81(3):459-66. PubMed PMID: 7776135.

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