Diclazuril sodium | CAS# 112209-99-1 (sodium) | coccidiostat and GAPDH inhibitor

MedKoo Cat#: 413701 | Name: Diclazuril sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diclazuril sodium is a coccidiostat and GAPDH inhibitor used to prevent parasitic contamination of livestock and poultry feed.

Chemical Structure

Diclazuril sodium

CAS#112209-99-1 (sodium)

Theoretical Analysis

MedKoo Cat#: 413701

Name: Diclazuril sodium

CAS#: 112209-99-1 (sodium)

Chemical Formula: C17H8Cl3N4NaO2

Exact Mass: 427.9611

Molecular Weight: 429.62

Elemental Analysis: C, 47.53; H, 1.88; Cl, 24.75; N, 13.04; Na, 5.35; O, 7.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

112209-98-0 (potassium) 101831-37-2 (free base) 112209-99-1 (sodium)

Synonym

Diclazuril Na; Sodium diclazuril; Diclazuril sodium;

IUPAC/Chemical Name

sodium 2-(3,5-dichloro-4-((4-chlorophenyl)(cyano)methyl)phenyl)-3,5-dioxo-2,5-dihydro-3H-1,2,4-triazin-4-ide

InChi Key

HMGDHGGCYNUBOJ-UHFFFAOYSA-M

InChi Code

InChI=1S/C17H9Cl3N4O2.Na/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24;/h1-6,8,12H,(H,23,25,26);/q;+1/p-1

SMILES Code

N#CC(C1=CC=C(Cl)C=C1)C2=C(Cl)C=C(N(C([N-]3)=O)N=CC3=O)C=C2Cl.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 429.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Huang Z, Guo D, Fan J, Zhong Y, Zhang M, He L, Zhang W. HPLC semi-preparative separation of diclazuril enantiomers and racemization in solution. J Sep Sci. 2020 Apr;43(7):1240-1247. doi: 10.1002/jssc.201901201. Epub 2020 Jan 15. PMID: 31909564. 2: EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Rychen G, Aquilina G, Azimonti G, Bampidis V, Bastos ML, Bories G, Chesson A, Cocconcelli PS, Flachowsky G, Kolar B, Kouba M, López Alonso M, López Puente S, Mantovani A, Mayo B, Ramos F, Saarela M, Villa RE, Wallace RJ, Wester P, Brantom P, Halle I, van Beelen P, Holczknecht O, Vettori MV, Gropp J. Safety and efficacy of Coxiril® (diclazuril) for chickens reared for laying. EFSA J. 2018 Mar 29;16(3):e05195. doi: 10.2903/j.efsa.2018.5195. PMID: 32625831; PMCID: PMC7009511. 3: EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Rychen G, Aquilina G, Azimonti G, Bampidis V, Bastos ML, Bories G, Chesson A, Cocconcelli PS, Flachowsky G, Kolar B, Kouba M, López-Alonso M, López Puente S, Mantovani A, Mayo B, Ramos F, Saarela M, Villa RE, Wallace RJ, Wester P, Brantom P, Halle I, van Beelen P, Holczknecht O, Vettori MV, Gropp J. Safety and efficacy of Coxiril® (diclazuril) for pheasants. EFSA J. 2018 Mar 22;16(3):e05196. doi: 10.2903/j.efsa.2018.5196. PMID: 32625832; PMCID: PMC7009574. 4: El-Ashram S, Aboelhadid SM, Arafa WM, Gadelhaq SM, Abdel-Razik AH. Protective potential of diclazuril-treated oocysts against coccidiosis in layer chicks. Vet Parasitol. 2019 Sep;273:105-111. doi: 10.1016/j.vetpar.2019.08.010. Epub 2019 Aug 20. PMID: 31473449. 5: Wang Z, Wu X, Liu L, Xu L, Kuang H, Xu C. Rapid and sensitive detection of diclazuril in chicken samples using a gold nanoparticle-based lateral-flow strip. Food Chem. 2020 May 15;312:126116. doi: 10.1016/j.foodchem.2019.126116. Epub 2019 Dec 26. PMID: 31901821. 6: Zhang M, Qiu J, Li X, Zhang W, Fan J, Zhou H, He L. Determination of residual enantiomers of diclazuril in chicken edible tissues by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jun 15;1118-1119:203-209. doi: 10.1016/j.jchromb.2019.04.042. Epub 2019 Apr 22. PMID: 31059927. 7: Zhou BH, Ding HY, Yang JY, Chai J, Guo HW, Wang HW. Effects of diclazuril on the expression of enolase in second-generation merozoites of Eimeria tenella. Poult Sci. 2020 Dec;99(12):6402-6409. doi: 10.1016/j.psj.2020.09.068. Epub 2020 Oct 7. PMID: 33248555; PMCID: PMC7705050. 8: El-Sawah AA, Aboelhadid SM, El-Nahass EN, Helal HE, Korany AM, El-Ashram S. Efficacy of probiotic Enterococcus faecium in combination with diclazuril against coccidiosis in experimentally infected broilers. J Appl Microbiol. 2020 Oct;129(4):1020-1028. doi: 10.1111/jam.14691. Epub 2020 May 26. PMID: 32364304. 9: Hunyadi L, Papich MG, Pusterla N. Diclazuril nonlinear mixed-effects pharmacokinetic modelling of plasma concentrations after oral administration to adult horses every 3-4 days. Vet J. 2018 Dec;242:74-76. doi: 10.1016/j.tvjl.2018.10.009. Epub 2018 Nov 8. PMID: 30503548. 10: Dirikolu L, Lehner F, Nattrass C, Bentz BG, Woods WE, Carter WG, Karpiesiuk W, Jacobs J, Boyles J, Harkins JD, Granstrom DE, Tobin T. Diclazuril in the horse: its identification and detection and preliminary pharmacokinetics. J Vet Pharmacol Ther. 1999 Dec;22(6):374-9. doi: 10.1046/j.1365-2885.1999.00232.x. PMID: 10651466.