MK-0249 is a histamine H3 inverse antagonist. Current antipsychotic treatments have little impact on the cognitive deficits associated with schizophrenia. It has been proposed that agents which promote histamine release may enhance cognition and, therefore, the H3 inverse agonist MK-0249 might improve cognitive deficits in patients with schizophrenia.
MedKoo Cat#: 577500
Name: MK-0249 mesylate
CAS#: MK-0249 mesylate
Chemical Formula: C23H24F3N3O2
Exact Mass: 431.1821
Molecular Weight: 431.46
Elemental Analysis: C, 64.03; H, 5.61; F, 13.21; N, 9.74; O, 7.42
The following data is based on the product molecular weight 431.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
