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MedKoo Cat#: 531011 | Name: Chlortetracycline Hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlortetracycline hydrochloride, also known as Aureomycin, is a broad-spectrum antibiotic used in veterinary medicine for pulmonary or digestive infections. Chlortetracycline and its metal complexes are toxic to bacteria when they are biologically available. Chlortetracycline and copper plus Chlortetracycline supplementation increased both the prevalence and gene copy numbers of tetA, while decreasing both the prevalence and gene copies of tetB.

Chemical Structure

Chlortetracycline Hydrochloride
Chlortetracycline Hydrochloride
CAS#64-72-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 531011

Name: Chlortetracycline Hydrochloride

CAS#: 64-72-2 (HCl)

Chemical Formula: C22H24Cl2N2O8

Exact Mass: 0.0000

Molecular Weight: 515.34

Elemental Analysis: C, 51.28; H, 4.69; Cl, 13.76; N, 5.44; O, 24.84

Price and Availability

Size Price Availability Quantity
5g USD 265.00 2 Weeks
10g USD 450.00 2 Weeks
25g USD 850.00 2 Weeks
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Related CAS #
57-62-5 (free) 27823-62-7 (bisulfate) 64-72-2 (HCl)
Synonym
Chlortetracycline hydrochloride, Chlortetracycline HCl, Chlortetracycline, Aureomycin, U-6780, U 6780, U6780, Clorocipan, Isphamycin
IUPAC/Chemical Name
(4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
InChi Key
CBHYYLPALVVVEY-MRFRVZCGSA-N
InChi Code
InChI=1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7-,8-,15-,21-,22-;/m0./s1
SMILES Code
O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])[C@](C)(O)C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4Cl)N.[H]Cl
Appearance
Light yellow to yellow solid powder.
Purity
>91% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 515.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 25131164; PubMed Central PMCID: PMC4461235. 4: Guo RX, Chen JQ. Phytoplankton toxicity of the antibiotic chlortetracycline and its UV light degradation products. Chemosphere. 2012 Jun;87(11):1254-9. doi: 10.1016/j.chemosphere.2012.01.031. Epub 2012 Feb 15. PubMed PMID: 22341398. 5: McDonald J. Chlortetracycline in calf milk replacer. Vet Rec. 2013 Sep 21;173(11):274-5. doi: 10.1136/vr.f5713. PubMed PMID: 24057498. 6: Pulicharla R, Das RK, Brar SK, Drogui P, Sarma SJ, Verma M, Surampalli RY, Valero JR. Toxicity of chlortetracycline and its metal complexes to model microorganisms in wastewater sludge. Sci Total Environ. 2015 Nov 1;532:669-75. doi: 10.1016/j.scitotenv.2015.05.140. Epub 2015 Jun 25. PubMed PMID: 26119381. 7: Daghrir R, Drogui P, Delegan N, El Khakani MA. Removal of chlortetracycline from spiked municipal wastewater using a photoelectrocatalytic process operated under sunlight irradiations. Sci Total Environ. 2014 Jan 1;466-467:300-5. doi: 10.1016/j.scitotenv.2013.07.001. Epub 2013 Jul 31. PubMed PMID: 23911841. 8: Agga GE, Scott HM, Vinasco J, Nagaraja TG, Amachawadi RG, Bai J, Norby B, Renter DG, Dritz SS, Nelssen JL, Tokach MD. Effects of chlortetracycline and copper supplementation on the prevalence, distribution, and quantity of antimicrobial resistance genes in the fecal metagenome of weaned pigs. Prev Vet Med. 2015 May 1;119(3-4):179-89. doi: 10.1016/j.prevetmed.2015.02.008. Epub 2015 Feb 23. PubMed PMID: 25745868. 9: Anadón A, Gamboa F, Martínez MA, Castellano V, Martínez M, Ares I, Ramos E, Suarez FH, Martínez-Larrañaga MR. Plasma disposition and tissue depletion of chlortetracycline in the food producing animals, chickens for fattening. Food Chem Toxicol. 2012 Aug;50(8):2714-21. doi: 10.1016/j.fct.2012.05.007. Epub 2012 May 14. PubMed PMID: 22595330. 10: Agga GE, Scott HM, Amachawadi RG, Nagaraja TG, Vinasco J, Bai J, Norby B, Renter DG, Dritz SS, Nelssen JL, Tokach MD. Effects of chlortetracycline and copper supplementation on antimicrobial resistance of fecal Escherichia coli from weaned pigs. Prev Vet Med. 2014 Jun 1;114(3-4):231-46. doi: 10.1016/j.prevetmed.2014.02.010. Epub 2014 Mar 5. PubMed PMID: 24655578. 11: Goossens J, Devreese M, Pasmans F, Osselaere A, De Baere S, Verbrugghe E, Haesebrouck F, De Backer P, Croubels S. Chronic exposure to the mycotoxin T-2 promotes oral absorption of chlortetracycline in pigs. J Vet Pharmacol Ther. 2013 Dec;36(6):621-4. doi: 10.1111/jvp.12059. Epub 2013 May 24. PubMed PMID: 23701633. 12: Ghoneim IM, Abdelghany AM, Waheed MM, Elmoslemany AM, Alhaider AK, Al-Eknah MM. Effect of oxytocin and PGF2α on chlortetracycline absorption from the uterus of early postpartum camels (Camelus dromedarius). Theriogenology. 2015 Sep 1;84(4):645-9. doi: 10.1016/j.theriogenology.2015.04.028. Epub 2015 May 4. PubMed PMID: 26004206. 13: Khan MH, Jung HS, Lee W, Jung JY. Chlortetracycline degradation by photocatalytic ozonation in the aqueous phase: mineralization and the effects on biodegradability. Environ Technol. 2013 Jan-Feb;34(1-4):495-502. PubMed PMID: 23530364. 14: Holman DB, Chénier MR. Impact of subtherapeutic administration of tylosin and chlortetracycline on antimicrobial resistance in farrow-to-finish swine. FEMS Microbiol Ecol. 2013 Jul;85(1):1-13. doi: 10.1111/1574-6941.12093. Epub 2013 Mar 11. PubMed PMID: 23397987. 15: Fernández-Calviño D, Bermúdez-Couso A, Arias-Estévez M, Nóvoa-Muñoz JC, Fernández-Sanjurjo MJ, Álvarez-Rodríguez E, Núñez-Delgado A. Competitive adsorption/desorption of tetracycline, oxytetracycline and chlortetracycline on two acid soils: Stirred flow chamber experiments. Chemosphere. 2015 Sep;134:361-6. doi: 10.1016/j.chemosphere.2015.04.098. Epub 2015 May 15. PubMed PMID: 25973861. 16: Fortushnyĭ VA, Ezhova OI. [The concentration of chlortetracyclin in the animal organism following various administration methods]. Veterinariia. 1966 Oct;43(10):51-2. Russian. PubMed PMID: 6012278. 17: Franc A, Lehocký R, Muselík J, Vetchý D, Dobšíková R, Modrá H. Preparation of feed premix for veterinary purposes. Ceska Slov Farm. 2014 Oct;63(5):213-6. PubMed PMID: 25354741. 18: Jin H, Chen X, Yang J, Wu L, Wang L. Hybrid intelligent control of substrate feeding for industrial fed-batch chlortetracycline fermentation process. ISA Trans. 2014 Nov;53(6):1822-37. doi: 10.1016/j.isatra.2014.08.015. Epub 2014 Sep 22. PubMed PMID: 25245525. 19: Liu M, Yao H, Liu H, Xu J, Zuo L. Feasibility of conventional and single-stage anaerobic ammonium oxidation processes for treating chlortetracycline wastewater. Water Sci Technol. 2014;70(6):947-54. doi: 10.2166/wst.2014.308. PubMed PMID: 25259481. 20: Juntunen P, Laurila T, Heinonen M, Hänninen ML. Absence of tetracycline resistance in Campylobacter coli isolates from Finnish finishing pigs treated with chlortetracycline. J Appl Microbiol. 2013 Apr;114(4):974-81. doi: 10.1111/jam.12120. Epub 2013 Feb 1. PubMed PMID: 23282197.