Midodrine (R-isomer HCl) | CAS#133163-28-7

MedKoo Cat#: 318270 | Name: Midodrine (R-isomer HCl)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Midodrine is a vasopressor/antihypotensive agent. It is indicated for the treatment of symptomatic orthostatic hypotension. It can reduce dizziness and faints by about a third, but can be limited by troublesome goose bumps. Small studies have also shown that midodrine can be used to prevent excessive drops in blood pressure in people requiring dialysis.

Chemical Structure

Midodrine (R-isomer HCl)

CAS#133163-28-7 (R-isomer HCl)

Theoretical Analysis

MedKoo Cat#: 318270

Name: Midodrine (R-isomer HCl)

CAS#: 133163-28-7 (R-isomer HCl)

Chemical Formula: C12H19ClN2O4

Exact Mass: 254.1267

Molecular Weight: 290.74

Elemental Analysis: C, 49.57; H, 6.59; Cl, 12.19; N, 9.64; O, 22.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

43218-56-0 (HCl) 42794-76-3 (free base) 133163-25-4 (R-isomer) 133163-28-7 (R-isomer HCl) 133267-39-7 (S-isomer)

Synonym

Midodrine, Amatine, ProAmatine, Gutron, ST-1085

IUPAC/Chemical Name

(R)-2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide hydrochloride

InChi Key

MGCQZNBCJBRZDT-PPHPATTJSA-N

InChi Code

InChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H/t10-;/m0./s1

SMILES Code

O=C(NC[C@@H](C1=CC(OC)=CC=C1OC)O)CN.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 290.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Izcovich A, González Malla C, Manzotti M, Catalano HN, Guyatt G. Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review. Neurology. 2014 Sep 23;83(13):1170-7. doi: 10.1212/WNL.0000000000000815. Epub 2014 Aug 22. Review. PubMed PMID: 25150287. 2: Parsaik AK, Singh B, Altayar O, Mascarenhas SS, Singh SK, Erwin PJ, Murad MH. Midodrine for orthostatic hypotension: a systematic review and meta-analysis of clinical trials. J Gen Intern Med. 2013 Nov;28(11):1496-503. doi: 10.1007/s11606-013-2520-3. Epub 2013 Jun 18. Review. PubMed PMID: 23775146; PubMed Central PMCID: PMC3797331. 3: Karwa R, Woodis CB. Midodrine and octreotide in treatment of cirrhosis-related hemodynamic complications. Ann Pharmacother. 2009 Apr;43(4):692-9. doi: 10.1345/aph.1L373. Epub 2009 Mar 18. Review. PubMed PMID: 19299324. 4: Rubinstein S, Haimov M, Ross MJ. Midodrine-induced vascular ischemia in a hemodialysis patient: a case report and literature review. Ren Fail. 2008;30(8):808-12. doi: 10.1080/08860220802249025. Review. PubMed PMID: 18791956. 5: Perazella MA. Efficacy and safety of midodrine in the treatment of dialysis-associated hypotension. Expert Opin Drug Saf. 2003 Jan;2(1):37-47. Review. PubMed PMID: 12904123. 6: Cruz DN. Midodrine: a selective alpha-adrenergic agonist for orthostatic hypotension and dialysis hypotension. Expert Opin Pharmacother. 2000 May;1(4):835-40. Review. PubMed PMID: 11249519. 7: Gilden JL. Midodrine in neurogenic orthostatic hypotension. A new treatment. Int Angiol. 1993 Jun;12(2):125-31. Review. PubMed PMID: 7690383. 8: Prakash S, Garg AX, Heidenheim AP, House AA. Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review. Nephrol Dial Transplant. 2004 Oct;19(10):2553-8. Epub 2004 Jul 27. Review. PubMed PMID: 15280522. 9: Barber DB, Rogers SJ, Fredrickson MD, Able AC. Midodrine hydrochloride and the treatment of orthostatic hypotension in tetraplegia: two cases and a review of the literature. Spinal Cord. 2000 Feb;38(2):109-11. Review. PubMed PMID: 10762185. 10: McClellan KJ, Wiseman LR, Wilde MI. Midodrine. A review of its therapeutic use in the management of orthostatic hypotension. Drugs Aging. 1998 Jan;12(1):76-86. Review. PubMed PMID: 9467688. 11: Piwinski SE, Jankovic J, McElligott MA. A comparison of postspace-flight orthostatic intolerance to vasovagal syncope and autonomic failure and the potential use of the alpha agonist midodrine for these conditions. J Clin Pharmacol. 1994 May;34(5):466-71. Review. PubMed PMID: 7522240. 12: McTavish D, Goa KL. Midodrine. A review of its pharmacological properties and therapeutic use in orthostatic hypotension and secondary hypotensive disorders. Drugs. 1989 Nov;38(5):757-77. Review. Erratum in: Drugs 1990 Feb;39(2):followi. PubMed PMID: 2480881.