RU24969 | CAS#66611-26-5 | 5-HT1A/5-HT1B receptor Agonist |MedKoo

MedKoo Cat#: 532595 | Name: RU24969 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RU-24,969 is a selective agonist at the 5-HT1A and 5-HT1B receptors, with preference for the latter. RU-24,969 has been found to increase the reinforcing properties of cocaine, suggesting a role for 5-HT1B receptors in cocaine addiction.

Chemical Structure

RU24969 free base

CAS#107008-28-6 (free base)

Theoretical Analysis

MedKoo Cat#: 532595

Name: RU24969 free base

CAS#: 107008-28-6 (free base)

Chemical Formula: C14H16N2O

Exact Mass: 228.1263

Molecular Weight: 228.30

Elemental Analysis: C, 73.66; H, 7.06; N, 12.27; O, 7.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

107008-28-6 (free base) 66611-27-6 (succinate)

Synonym

RU 24969; RU-24969; RU24969.

IUPAC/Chemical Name

5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole

InChi Key

KRVMLPUDAOWOGN-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3

SMILES Code

COC1=CC2=C(NC=C2C3=CCNCC3)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 228.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Aronsen D, Bukholt N, Schenk S. Repeated administration of the 5-HT₁B/₁A agonist, RU 24969, facilitates the acquisition of MDMA self-administration: role of 5-HT₁A and 5-HT₁B receptor mechanisms. Psychopharmacology (Berl). 2016 Apr;233(8):1339-47. doi: 10.1007/s00213-016-4225-x. Epub 2016 Feb 9. PubMed PMID: 26856853. 2: Aronsen D, Webster J, Schenk S. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep;124:1-4. doi: 10.1016/j.pbb.2014.05.008. Epub 2014 May 15. PubMed PMID: 24844705. 3: Martinez-Price DL, Geyer MA. Subthalamic 5-HT(1A) and 5-HT(1B) receptor modulation of RU 24969-induced behavioral profile in rats. Pharmacol Biochem Behav. 2002 Apr;71(4):569-80. PubMed PMID: 11888548.